Scoping review of data and methods used in studies that estimated Covid-19 vaccine effectiveness in reducing cause-specific and all-cause mortality during the SARS-CoV-2 pandemic

  • Stehlik, Paulina (Project Lead)
  • Byambasuren, Oyuka (Project Roles)
  • Falster, Micheal (Associate Investigator)
  • Pratt, Nichole (Associate Investigator)
  • Pearson, Sallie Anne (Associate Investigator)
  • Nasreen, Shafira (Associate Investigator)
  • Camacho, Ximena (Associate Investigator)
  • Henry, David (Chief Investigator)

Project: Research

Project Details


2022 MI-CRE Incubator Grant: $22,000

Plain Language description

Pharmacoepidemiology has largely been concerned with quantification of uncommon harms from medications. Estimating effectiveness is more challenging, because of potentially greater confounding and selection biases. Covid-19 vaccines were developed in a remarkably short time frame and have been administered to billions of individuals. Vaccination programs have engendered a very large and growing literature on vaccine effectiveness.

Most of the information on Covid-19 vaccine effectiveness we now rely on comes from ‘real world’ studies. As of September 2022, an international database contains details of over 300 effectiveness studies conducted in over 35 countries over approximately 18 months. Over 60 of these studies report on vaccine effects on mortality. In the field of pharmaco-epidemiology this is a unique database on the derivation of effectiveness estimates from routinely collected data. These studies have used a variety of different types of data and analytical methods and results were generally strongly positive in terms of vaccine effectiveness.

We plan a scoping review of these studies to learn best practices in terms of data quality, cohort definition, analysis, and techniques to minimise bias when estimating effectiveness. The review findings will be used to guide present and future vaccine effectiveness studies and will help guide real world effectiveness studies of other medicines being evaluated in our CRE.

Project Aims

Which data sources, designs, and analytical methods are currently being used in evaluating post-licensing Covid-19 vaccine effectiveness (mortality reduction) studies?
Which are best at reducing bias?
Effective start/end date17/01/23 → …


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