• Bond University, Faculty of Health Sciences and Medicine

    4229 Gold Coast

    Australia

  • Centre for Urology Research Bond University 14 University Drive, ROBINA QLD 4229

    Australia

  • 33 Citations
  • 3 h-Index
20092019
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Personal profile

Research interests

Current research interests include:

  • The development of novel cancer therapies. This includes the design and synthesis of PARP14 inhibitors and prostate cancer research in collaboration with Dr Luke Henderson (from Deakin University).
  • The analysis of supplements using HPLC. Examples of supplements that have been analysed include sporting supplements and ginger extracts.
  • The development of antibiotics and anti-tubercular compounds. 'Superbugs' are a real thing!

Research Experience:

  • Research project (2006-2007) Synthesis of Carbohydrates. Dr. Darren Grice, Griffith University, Institute for Glycomics, Gold Coast, Australia.
  • Research project (2010) Synthesis of target nitroxide used for clinical trials. Prof Steven Bottle and Dr Kathryn Fairfull-Smith, Queensland University of Technology, Brisbane, Australia.
  • Research project (2010) Boranic acids as fluorescence sensors. Dr. Todd Houston, Griffith University, Institute for glycomics, Gold Coast, Australia.
  • Postdoctoral research project (2011) IR spectroscopy/electrochemistry of lipid bilayers and redox proteins. Dr. Andreas Erbe, Interface Spectroscopy group, Max-Planck-Institute Germany.

 

Statement for HDR students

Projects are available for potential HDR and project students in the areas of novel drug design and development towards the treatment of cancers or analysis of supplements.

Laboratory Techniques that will be employed include:

  • Molecular modelling
  • Computational chemistry
  • Structure-Activity Relationship determination
  • Organic synthesis
  • Peptide synthesis 
  • Chemical analysis.

 

Education/Academic qualification

Organic Chemistry, PhD, Griffith University Queensland

External positions

Griffith University Queensland

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Research Output 2009 2019

  • 33 Citations
  • 3 h-Index
  • 9 Article
  • 1 Meeting Abstract

Structure, function and inhibition of poly(ADP-ribose)polymerase, member 14 (PARP14)

Schweiker, S. S., Tauber, A., Sherry, M. & Levonis, S. M., 2018, In : Mini-Reviews in Medicinal Chemistry. 18, 19, p. 1659-1669 11 p.

Research output: Contribution to journalArticle

Poly(ADP-ribose) Polymerases
Adenosine Diphosphate Ribose
NAD
Catalytic Domain
ADP Ribose Transferases
3 Citations

A practical guide to molecular docking and homology modelling for medicinal chemists

Lohning, A. E., Levonis, S. M., Williams-Noonan, B. & Schweiker, S. S., 30 Jan 2017, In : Current Topics in Medicinal Chemistry. 17, 32, p. 2023-2040 8 p.

Research output: Contribution to journalArticle

Open Access
File
Ligands
X-Rays
Benchmarking
Androgen Antagonists
Drug Discovery
3 Citations

2-Oxo-1,2-dihydropyridinyl-3-yl amide-based GPa inhibitors: Design, synthesis and structure-activity relationship study

Loughlin, W. A., Jenkins, I. D., Karis, N. D., Schweiker, S. S. & Healy, P. C., 23 Mar 2016, In : European Journal of Medicinal Chemistry. 111, p. 1-14 14 p.

Research output: Contribution to journalArticle

Glycogen Phosphorylase
Structure-Activity Relationship
Amides
Inhibitory Concentration 50
Lead compounds

Can we "starve cancer cells to death" with selective parp14 inhibitors?

Schweiker, S. S. & Levonis, S. M., Nov 2016, In : Asia-Pacific Journal of Clinical Oncology. 12, p. 114-114 1 p., 206.

Research output: Contribution to journalMeeting Abstract

Open Access