Research Output per year
Personal profile
Research interests
Laboratory studies to enhance our knowledge of the lower urinary tract, with the aim of developing new treatments, or enhancing current treatments of the following conditions:
- Overactive bladder
- Cancers of the lower urinary tract
- Stress incontinence
- Ureteral stones
- Benign prostatic hyperplasia
- Erectile dysfunction
Statement for HDR students
The research group specialises in studies of the lower urinary tract using isolated tissues to examine contraction, biochemical assays to measure release of ATP, acetylcholine and prostaglandins, histological techniques to examine structure and protein distribution, molecular biology techniques to measure proteins and radioligand binding to measure receptor densities and characteristics.
Current projects examine the receptors and ion channels of the bladder, urethra, ureter, prostate and cavernosum to identify new targets for drugs to treat overactive bladder, stress incontinence, renal stones, and enlarged prostate and erectile dysfunction.
Recent studies also include the effects of cytotoxic drugs and metabolites on bladder function to identify the causes of side effects, interactions between anti-cancer drugs, and treatments to enhance the effects of radiotherapy and other cytotoxic drugs.
Education/Academic qualification
Pharmacology, PhD, University of Wales
External positions
University of Sheffield
1990 → Mar 2006Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.
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Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Research Output 1988 2018
5-HT2A receptor is the predominant receptor mediating contraction of the isolated porcine distal ureter to 5-HT in young and old animals
Lim, I., Chess-Williams, R. & Sellers, D., 5 Jan 2018, In : European Journal of Pharmacology. 818, p. 328-334 7 p.Research output: Contribution to journal › Article › Research › peer-review
Receptor, Serotonin, 5-HT2A
Ureter
Swine
Area Under Curve
Methiothepin
A central role for toll-like 4 (TLR4) receptors in interstitial cystitis?
Sellers, D. J., McDermott, C. & Chess-Williams, R., 27 Jun 2018, In : American Journal of Physiology - Renal Physiology.Research output: Contribution to journal › Article › Research › peer-review
Interstitial Cystitis
Toll-Like Receptor 4
Urinary Bladder
Pain
Anxiety
Altered ureteral contractility with ageing: Role of the rho-kinase pathway
Lim, I., Chess-Williams, R. & Sellers, D., 1 Apr 2018, In : Mechanisms of Ageing and Development. 171, p. 31-36 6 p.Research output: Contribution to journal › Article › Research › peer-review
rho-Associated Kinases
Phenylephrine
Serotonin
Ureter
Area Under Curve
Diabetes-induced alterations in urothelium function: Enhanced ATP release and nerve-evoked contractions in the streptozotocin rat bladder
Lee, S., Rose'meyer, R., McDermott, C., Chess-Williams, R. & Sellers, D. J., 1 Nov 2018, In : Clinical and Experimental Pharmacology and Physiology. 45, 11, p. 1161-1169 9 p.Research output: Contribution to journal › Article › Research › peer-review
Urothelium
Streptozocin
Urinary Bladder
Adenosine Triphosphate
Compliance
Ibuprofen decreases spontaneous activity and enhances nerve-evoked contractions to minimize mitomycin c-induced bladder dysfunction
West, E. G., Lang, R., Sellers, D., Chess-Williams, R. & McDermott, C., 1 Aug 2018, In : Journal of Pharmacology and Experimental Therapeutics. 366, 2, p. 282-290 9 p.Research output: Contribution to journal › Article › Research › peer-review
Ibuprofen
Mitomycin
Urinary Bladder
Caspase 3
Inbred C57BL Mouse
Activities 2018 2018
- 1 Oral presentation
Speed Research Presentations
Elisabeth Isenring (Speaker), Jaimon T Kelly (Speaker), Christian Moro (Speaker), Mark Morgan (Speaker), Anna V. Lorimer (Speaker), Vernon G Coffey (Speaker), Rae Louise Thomas (Speaker), Alexandra Bannach-Brown (Speaker), Ray N Moynihan (Speaker), Daniel Maupin (Speaker), Rob Marc Orr (Speaker), Nigel L Barnett (Speaker), Russ Chess-Williams (Speaker)21 Nov 2018
Activity: Talk or presentation › Oral presentation
Student theses
Amphetamine-like compounds in pre-workout supplements
Author: Koh, A., 10 Jun 2017Supervisor: Lohning, A. E. (Supervisor) & Chess-Williams, R. G. (Supervisor)
Student thesis: Master's Thesis
File
Contractile activity of the bladder urothelium and lamina propria
Author: Moro, C., 9 Feb 2013Supervisor: Chess-Williams, R. (Supervisor) & Sellers, D. J. (Supervisor)
Student thesis: Doctoral Thesis
File
Cyclophosphamide and ifosfamide: mechanisms of cytotoxic action and consequences for normal bladder function
Author: Mills, K., 10 Oct 2015Supervisor: Chess-Williams, R. G. (Supervisor) & McDermott, C. (Supervisor)
Student thesis: Doctoral Thesis
File
Cytotoxic Drugs and their Effects on Bladder Function
Author: Kang, S. H., 10 Oct 2015Supervisor: McDermott, C. (Supervisor) & Chess-Williams, R. G. (Supervisor)
Student thesis: Doctoral Thesis
File
Drug targets for urinary and faecal incontinence and anal fissure
Author: Folasire, O., 11 Feb 2017Supervisor: Sellers, D. J. (Supervisor) & Chess-Williams, R. G. (Supervisor)
Student thesis: Doctoral Thesis
File