Research Output per year
Personal profile
Research interests
Laboratory studies to enhance our knowledge of the lower urinary tract, with the aim of developing new treatments, or enhancing current treatments of the following conditions:
- Overactive bladder
- Cancers of the lower urinary tract
- Stress incontinence
- Ureteral stones
- Benign prostatic hyperplasia
- Erectile dysfunction
Statement for HDR students
The research group specialises in studies of the lower urinary tract using isolated tissues to examine contraction, biochemical assays to measure release of ATP, acetylcholine and prostaglandins, histological techniques to examine structure and protein distribution, molecular biology techniques to measure proteins and radioligand binding to measure receptor densities and characteristics.
Current projects examine the receptors and ion channels of the bladder, urethra, ureter, prostate and cavernosum to identify new targets for drugs to treat overactive bladder, stress incontinence, renal stones, and enlarged prostate and erectile dysfunction.
Recent studies also include the effects of cytotoxic drugs and metabolites on bladder function to identify the causes of side effects, interactions between anti-cancer drugs, and treatments to enhance the effects of radiotherapy and other cytotoxic drugs.
Education/Academic qualification
Pharmacology, PhD, University of Wales
External positions
University of Sheffield
1990 → Mar 2006Fingerprint Dive into the research topics where Russ Chess-Williams is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 4 Similar Profiles
Urinary Bladder
Medicine & Life Sciences
Urothelium
Medicine & Life Sciences
Adrenergic Receptors
Medicine & Life Sciences
Swine
Medicine & Life Sciences
Muscarinic Receptors
Medicine & Life Sciences
Carbachol
Medicine & Life Sciences
Mucous Membrane
Medicine & Life Sciences
tamsulosin
Medicine & Life Sciences
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Research Output 1988 2019
Differential mechanisms of action of the trace amines octopamine, synephrine and tyramine on the porcine coronary and mesenteric artery
Koh, A., Chess-Williams, R. & Lohning, A. E., 29 Jul 2019, In : Scientific Reports. 9, 9 p., 10925.Research output: Contribution to journal › Article › Research › peer-review
Open Access
File
mesenteric arteries
octopamine
tyramine
coronary vessels
amines
Elevated release of inflammatory but not sensory mediators from the urothelium is maintained following epirubicin treatment
Kang, S. H., Chess-Williams, R. & McDermott, C., 1 Oct 2019, In : European Journal of Pharmacology. 863, 9 p., 172703.Research output: Contribution to journal › Article › Research › peer-review
Urothelium
Epirubicin
Cytokines
Acetylcholine
Interleukin-8
Histamine modulation of urinary bladder urothelium, lamina propria and detrusor contractile activity via H1 and H2 receptors
Stromberga, Z., Chess-Williams, R. & Moro, C., 7 Mar 2019, In : Scientific Reports. 9, 1, 7 p., 3899.Research output: Contribution to journal › Article › Research › peer-review
Open Access
File
Urothelium
Histamine H1 Receptors
Histamine H2 Receptors
Histamine
Mucous Membrane
Novel insights into the mechanism of cyclophosphamide-induced bladder toxicity: chloroacetaldehyde's contribution to urothelial dysfunction in vitro
Mills, K. A., Chess-Williams, R. & McDermott, C., 9 Oct 2019, In : Archives of Toxicology.Research output: Contribution to journal › Article › Research › peer-review
Acrolein
Cyclophosphamide
Toxicity
Acetylcysteine
Urinary Bladder
1
Citation
(Scopus)
70
Downloads
(Pure)
5-HT2A receptor is the predominant receptor mediating contraction of the isolated porcine distal ureter to 5-HT in young and old animals
Lim, I., Chess-Williams, R. & Sellers, D., 5 Jan 2018, In : European Journal of Pharmacology. 818, p. 328-334 7 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access
File
Receptor, Serotonin, 5-HT2A
Ureter
Swine
Area Under Curve
Methiothepin
Activities 2018 2018
- 1 Oral presentation
Speed Research Presentations
Elisabeth Isenring (Speaker), Jaimon T Kelly (Speaker), Christian Moro (Speaker), Mark Morgan (Speaker), Anna V. Lorimer (Speaker), Vernon G Coffey (Speaker), Rae Louise Thomas (Speaker), Alexandra Bannach-Brown (Speaker), Ray N Moynihan (Speaker), Daniel Maupin (Speaker), Rob Marc Orr (Speaker), Nigel L Barnett (Speaker), Russ Chess-Williams (Speaker)21 Nov 2018
Activity: Talk or presentation › Oral presentation
Press / Media
Bond establishes new Centre for Urology Research
29/07/15
1 item of media coverage
Press/Media: Expert Comment
Uni lifts research
Helen O'Neill & Russ Chess-Williams
15/07/15
1 item of media coverage
Press/Media: Expert Comment
Bond expands medical research centre
Helen O'Neill & Russ Chess-Williams
14/07/15
2 items of media coverage
Press/Media: Expert Comment
Student theses
Amphetamine-like compounds in pre-workout supplements
Author: Koh, A., 10 Jun 2017Supervisor: Lohning, A. E. (Supervisor) & Chess-Williams, R. G. (Supervisor)
Student thesis: Master's Thesis
File
Contractile activity of the bladder urothelium and lamina propria
Author: Moro, C., 9 Feb 2013Supervisor: Chess-Williams, R. (Supervisor) & Sellers, D. J. (Supervisor)
Student thesis: Doctoral Thesis
File
Cyclophosphamide and ifosfamide: mechanisms of cytotoxic action and consequences for normal bladder function
Author: Mills, K., 10 Oct 2015Supervisor: Chess-Williams, R. G. (Supervisor) & McDermott, C. (Supervisor)
Student thesis: Doctoral Thesis
File
Cytotoxic Drugs and their Effects on Bladder Function
Author: Kang, S. H., 10 Oct 2015Supervisor: McDermott, C. (Supervisor) & Chess-Williams, R. G. (Supervisor)
Student thesis: Doctoral Thesis
File
Drug targets for urinary and faecal incontinence and anal fissure
Author: Folasire, O., 11 Feb 2017Supervisor: Sellers, D. J. (Supervisor) & Chess-Williams, R. G. (Supervisor)
Student thesis: Doctoral Thesis
File