Research output per year
Research output per year
Personal profile
Research interests
Laboratory studies to enhance our knowledge of the lower urinary tract, with the aim of developing new treatments, or enhancing current treatments of the following conditions:
- Overactive bladder
- Cancers of the lower urinary tract
- Stress incontinence
- Ureteral stones
- Benign prostatic hyperplasia
- Erectile dysfunction
Statement for HDR students
The research group specialises in studies of the lower urinary tract using isolated tissues to examine contraction, biochemical assays to measure release of ATP, acetylcholine and prostaglandins, histological techniques to examine structure and protein distribution, molecular biology techniques to measure proteins and radioligand binding to measure receptor densities and characteristics.
Current projects examine the receptors and ion channels of the bladder, urethra, ureter, prostate and cavernosum to identify new targets for drugs to treat overactive bladder, stress incontinence, renal stones, and enlarged prostate and erectile dysfunction.
Recent studies also include the effects of cytotoxic drugs and metabolites on bladder function to identify the causes of side effects, interactions between anti-cancer drugs, and treatments to enhance the effects of radiotherapy and other cytotoxic drugs.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Pharmacology, PhD, University of Wales
Award Date: 29 Jan 1984
External positions
University of Sheffield
1990 → Mar 2006Fingerprint
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Research output
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17β-estradiol and ureteral contractility: A role for the G protein-coupled estrogen receptor
Lim, I., Christiansen, C. & Chess-Williams, R., 15 May 2021, In: European Journal of Pharmacology. 899, 174024.Research output: Contribution to journal › Article › Research › peer-review
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Bladder overactivity induced by psychological stress in female mice is associated with enhanced bladder contractility
West, E., Sellers, D. J., Chess-Williams, R. & McDermott, C., 15 Jan 2021, In: Life Sciences. 265, 8 p., 118735.Research output: Contribution to journal › Article › Research › peer-review
4 Citations (Scopus) -
Chronic psychological stress and lower urinary tract symptoms
Chess-Williams, R., McDermott, C., Sellers, D. J., West, E. G. & Mills, K. A., 16 Jun 2021, (E-pub ahead of print) In: LUTS: Lower Urinary Tract Symptoms.Research output: Contribution to journal › Review article › Research › peer-review
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Comparative effects of angiotensin II on the contractility of muscularis mucosae and detrusor in the pig urinary bladder
Lim, I., Mitsui, R., Kameda, M., Sellers, D. J., Chess-Williams, R. & Hashitani, H., Jan 2021, In: Neurourology and Urodynamics. 40, 1, p. 102-111 10 p.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile -
Current and emerging pharmacological targets for medical expulsive therapy
Lim, I., Sellers, D. J. & Chess-Williams, R., 24 May 2021, (E-pub ahead of print) In: Basic and Clinical Pharmacology and Toxicology.Research output: Contribution to journal › Review article › Research › peer-review
Open Access
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Inaugural Virtual Education Symposium
Iris Lim (Organiser), Donna Sellers (Organiser), Russ Chess-Williams (Organiser) & Betty Exintaris (Participant)
Dec 2020 → …Activity: Participating in or organising an event › Organising a conference, workshop, ...
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Speed Research Presentations
Elisabeth Isenring (Speaker), Jaimon T Kelly (Speaker), Christian Moro (Speaker), Mark Morgan (Speaker), Anna V. Lorimer (Speaker), Vernon G Coffey (Speaker), Rae Louise Thomas (Speaker), Alexandra Bannach-Brown (Speaker), Ray N Moynihan (Speaker), Daniel Maupin (Speaker), Rob Marc Orr (Speaker), Nigel L Barnett (Speaker) & Russ Chess-Williams (Speaker)
21 Nov 2018Activity: Talk or presentation › Oral presentation
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National Conference on Incontinence Pre-Conference Workshop
Donna Sellers (Speaker), Christian Moro (Speaker), Russ Chess-Williams (Facilitator) & Catherine McDermott (Speaker)
19 Oct 2020 → …Activity: Participating in or organising an event › Organising a conference, workshop, ...