• Bond University, Faculty of Health Sciences and Medicine

    4229 Gold Coast


Accepting PhD Students

  • 476 Citations
  • 12 h-Index
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Personal profile

Research interests

I completed my PhD studies in stem cells and hematopoiesis at the Australian National University. In 2009, I moved to Kyoto University under a Japan Society for Promotion of Science (JSPS) Postdoctoral Fellowship to specialise in artificial lymphoid tissue development. In 2011, I was awarded a 4 year NHMRC CJ Martin Biomedical Fellowship to continue research in both Japan and Australia. In 2015, I received NHMRC New Investigator Project Grant funding, and moved to Bond University where I am continuing research in spleen regeneration.

I am now head of the Lymphoid Tissue Regeneration Lab at the Clem Jones Centre for Regenerative Medicine. My research team focuses on spleen as a secondary lymphoid organ, and it’s ability to regenerate and support extramedullary hematopoiesis. Research in this area involves the use of spleen tissue grafting and regeneration models, isolating and transplanting hematopoietic stem cells, single cell sorting, and transcriptome profiling.

Statement for HDR students

A range of student projects aiming to dissect the mechanisms of spleen regeneration are available in our lab. The projects combine cell sorting, graft transplantation, immunofluorescence microscopy and reporter/knockout mouse models to investigate three central questions:

  • What is the lineage origin and potential of stromal organiser cells that induce spleen tissue regeneration?
  • What are the minimal cell requirements for spleen development
  • Which genes and ligand/receptor interactions confer tissue organising capacity to stromal cells?

Education/Academic qualification

Hematopoiesis, PhD, Australian National University

External positions

Lab Leader, Australian National University

Jul 2013Jun 2015

Postdoctoral Fellow, Kyoto University

Jul 2009Jun 2013

Fingerprint Dive into the research topics where Jonathan Tan is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 2 Similar Profiles
Spleen Medicine & Life Sciences
Dendritic Cells Medicine & Life Sciences
Hematopoiesis Medicine & Life Sciences
Stromal Cells Medicine & Life Sciences
Hematopoietic Stem Cells Medicine & Life Sciences
Myeloid Cells Medicine & Life Sciences
Antigen-Presenting Cells Medicine & Life Sciences
Regeneration Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 2005 2019

Gene profiling murine splenic stromal lines: ArrayExpress Database Accession number E-MTAB-8345

O'Neill, H. C., Lim, D., Periasamy, P., Kumarappan, L., Tan, J. K. H. & O'Neill, T., 10 Oct 2019, European Bioinformatics Institute (EMBL-EBI).

Research output: Other contributionResearchpeer-review

Open Access
Cell Lineage
Stromal Cells
1 Citation (Scopus)
169 Downloads (Pure)

Targeting the Spleen as an Alternative Site for Hematopoiesis

Short, C., Lim, H., Tan, J. K. H. & O'Neill, H. C., May 2019, In : BioEssays. 41, 5, p. 1-9 9 p., 1800234.

Research output: Contribution to journalArticleResearchpeer-review

Stem cells
32 Downloads (Pure)

Transplanted spleen stromal cells with osteogenic potential support ectopic myelopoiesis

O'Neill, H. C., Lim, H. K., Periasamy, P., Kumarappan, L., Tan, J. K. H. & O'Neill, T. J., 4 Oct 2019, In : PLoS One. 14, 10, e0223416.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
stromal cells
Stromal Cells
96 Downloads (Pure)

Determinants of postnatal spleen tissue regeneration and organogenesis

Tan, J. K. H. & Watanabe, T., 16 Jan 2018, In : npj Regenerative Medicine. 3, 4 p.

Research output: Contribution to journalReview articleResearchpeer-review

Open Access
Tissue regeneration
10 Citations (Scopus)

Origin and Immunological Functions of Spleen Stromal Cells

Golub, R., Tan, J., Watanabe, T. & Brendolan, A., Jun 2018, In : Trends in Immunology. 39, 6, p. 503-514 12 p.

Research output: Contribution to journalReview articleResearchpeer-review

Stromal Cells
Extramedullary Hematopoiesis
Immune System
Wounds and Injuries

Activities 2015 2019

  • 2 Talk or Presentation Outside of an Organised Event
  • 1 Invited talk

Online Tools for Managing Your Research (CloudStor, LabArchives, Quartzy)

Karin Tourle (Speaker), Jonathan Tan (Speaker)
5 Feb 2019

Activity: Talk or presentationTalk or Presentation Outside of an Organised EventOral Presentation

How does spleen regenerate?

Jonathan Tan (Speaker)
15 Jan 2015

Activity: Talk or presentationInvited talk

Biomed Presentation: Research Data Management Tools

Karin Tourle (Speaker), Jonathan Tan (Speaker)
1 Mar 2019

Activity: Talk or presentationTalk or Presentation Outside of an Organised EventOral Presentation