Photo of Jonathan Tan
  • Bond University, Faculty of Health Sciences and Medicine

    4229 Gold Coast

    Australia

Accepting PhD Students

  • 506 Citations
  • 13 h-Index
20052019

Research output per year

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Personal profile

Research interests

I completed my PhD studies in stem cells and hematopoiesis at the Australian National University. In 2009, I moved to Kyoto University under a Japan Society for Promotion of Science (JSPS) Postdoctoral Fellowship to specialise in artificial lymphoid tissue development. In 2011, I was awarded a 4 year NHMRC CJ Martin Biomedical Fellowship to continue research in both Japan and Australia. In 2015, I received NHMRC New Investigator Project Grant funding, and moved to Bond University where I am continuing research in spleen regeneration.

I am now head of the Lymphoid Tissue Regeneration Lab at the Clem Jones Centre for Regenerative Medicine. My research team focuses on spleen as a secondary lymphoid organ, and it’s ability to regenerate and support extramedullary hematopoiesis. Research in this area involves the use of spleen tissue grafting and regeneration models, isolating and transplanting hematopoietic stem cells, single cell sorting, and transcriptome profiling.

Statement for HDR students

A range of student projects aiming to dissect the mechanisms of spleen regeneration are available in our lab. The projects combine cell sorting, graft transplantation, immunofluorescence microscopy and reporter/knockout mouse models to investigate three central questions:

  • What is the lineage origin and potential of stromal organiser cells that induce spleen tissue regeneration?
  • What are the minimal cell requirements for spleen development
  • Which genes and ligand/receptor interactions confer tissue organising capacity to stromal cells?

Education/Academic qualification

Hematopoiesis, PhD, Australian National University

Award Date: 3 Mar 2009

External positions

Lab Leader, Australian National University

Jul 2013Jun 2015

Postdoctoral Fellow, Kyoto University

Jul 2009Jun 2013

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Research Output

Gene profiling murine splenic stromal lines: ArrayExpress Database Accession number E-MTAB-8345

O'Neill, H. C., Lim, D., Periasamy, P., Kumarappan, L., Tan, J. K. H. & O'Neill, T., 10 Oct 2019, European Bioinformatics Institute (EMBL-EBI).

Research output: Other contributionResearchpeer-review

Open Access
  • Targeting the Spleen as an Alternative Site for Hematopoiesis

    Short, C., Lim, H., Tan, J. K. H. & O'Neill, H. C., May 2019, In : BioEssays. 41, 5, p. 1-9 9 p., 1800234.

    Research output: Contribution to journalArticleResearchpeer-review

    Open Access
    File
  • 4 Citations (Scopus)
    300 Downloads (Pure)

    Transplanted spleen stromal cells with osteogenic potential support ectopic myelopoiesis

    O'Neill, H. C., Lim, H. K., Periasamy, P., Kumarappan, L., Tan, J. K. H. & O'Neill, T. J., 4 Oct 2019, In : PLoS One. 14, 10, 25 p., e0223416.

    Research output: Contribution to journalArticleResearchpeer-review

    Open Access
    File
  • 78 Downloads (Pure)

    Determinants of postnatal spleen tissue regeneration and organogenesis

    Tan, J. K. H. & Watanabe, T., 16 Jan 2018, In : npj Regenerative Medicine. 3, 4 p., 1.

    Research output: Contribution to journalReview articleResearchpeer-review

    Open Access
    File
  • 2 Citations (Scopus)
    158 Downloads (Pure)

    Origin and Immunological Functions of Spleen Stromal Cells

    Golub, R., Tan, J., Watanabe, T. & Brendolan, A., Jun 2018, In : Trends in Immunology. 39, 6, p. 503-514 12 p.

    Research output: Contribution to journalReview articleResearchpeer-review

  • 15 Citations (Scopus)

    Activities

    • 2 Talk or Presentation Outside of an Organised Event
    • 1 Invited talk

    Biomed Presentation: Research Data Management Tools

    Karin Tourle (Speaker) & Jonathan Tan (Speaker)

    1 Mar 2019

    Activity: Talk or presentationTalk or Presentation Outside of an Organised EventOral Presentation

    Online Tools for Managing Your Research (CloudStor, LabArchives, Quartzy)

    Karin Tourle (Speaker) & Jonathan Tan (Speaker)

    5 Feb 2019

    Activity: Talk or presentationTalk or Presentation Outside of an Organised EventOral Presentation

    How does spleen regenerate?

    Jonathan Tan (Speaker)

    15 Jan 2015

    Activity: Talk or presentationInvited talk