Personal profile
Research interests
My research experience has been in the fields of stem cell biology and immunology. I have a history of publication in experimental hematology and the development of hematopoietic cells from stem cells. A more recent interest is stromal cell microenvironments which support hematopoietic and mesenchymal stem cell development for tissue regeneration. I also have a long-term interest in lymphocyte and dendritic cell development and function. Recent important findings relate to hematopoiesis which occurs in spleen, and definition of myelopoiesis unique to spleen.
Since joining Bond University in 2015 I have been involved in retinal cell differentiation with a view to development of a stem cell therapy for treatment of age-related macular degeneration. This involves preparation of retinal pigment epithelial cells from pluripotent stem cells, growth of cells on a membrane, and implantation into the subretinal space. The goal is to achieve vision improvement through replacement of the retinal pigment epithelial cells which support photoreceptor function, but which are lost in macular degeneration.
Education/Academic qualification
Immunology, PhD, H-2 antigenic requirements for T cell recognition, Australian National University
Award Date: 1 Jan 1981
Genetics, BSc Hons I, University of Adelaide
Administration, GD (Admin), University of Canberra
External positions
Emeritus Professor, Australian National University
Former Fellow, Stanford University
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Collaborations and top research areas from the last five years
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Assessing The Role of Spleen in Development of Myeloid Bias Amongst Haematopoietic Stem Cells
Short, C., O'Neill, H. C. & Tan, J. K. H., 17 Dec 2024, In: International Journal of Stem Cells and Medicine. 3, 2, p. 1-16 16 p.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile62 Downloads (Pure) -
Characterisation of Stromal Cells Which Support Hematopoietic Niches in Murine Spleen
Lim, H. K. & O'Neill, H. C., 29 Jul 2024, In: International Journal of Stem Cells and Medicine. 3, 1Research output: Contribution to journal › Article › Research › peer-review
Open Access -
Cytocompatibility of electrospun poly-L-lactic acid membranes for Bruch's membrane regeneration using human embryonic stem cell-derived retinal pigment epithelial cells
Abbasi, N. & O'Neill, H., 10 May 2024, In: Journal of Biomedical Materials Research - Part A. 112, 11, p. 1902-1920 19 p.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile160 Downloads (Pure) -
Exploring the regenerative capacity of the spleen following irradiation
Short, C., O'Neill, H. C. & Tan, J. K. H., 26 Nov 2024, In: Frontiers in Hematology. 3, p. 1-16 16 p., 1396672.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile71 Downloads (Pure) -
Investigating AMD retinal biomarkers in a rat model of CNV
Mammone, T., O'Neill, H. C. & Barnett, N. L., May 2024, p. 1-1. 1 p.Research output: Contribution to conference › Poster › Research › peer-review
Open AccessFile25 Downloads (Pure)
Activities
- 1 Oral presentation
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Hyperreflective foci in a rat model of choroidal neovascularization
Mammone, T. (Speaker), O'Neill, H. (Speaker) & Barnett, N. (Speaker)
2023Activity: Talk or presentation › Oral presentation