Research Output per year
Personal profile
Research interests
My research experience has been in the fields of immunology and experimental hematology and the development of hematopietic cells from stem cells.
My lab has developed new and exacting culture methods and stem cell isolation procedures that will form the basis of future work on stem cells and tissue regeneration. Recent important findings relate to hematopoiesis which occurs in spleen, and definition of myelopoiesis unique to spleen.
I have a particular interest in stromal cell microenvironments which support hematopoietic and mesenchymal stem cell development for tissue regeneration, and a long standing interest in lymphocyte and dendritic cell development and function.
Statement for HDR students
A range of student projects are available related to stem cells, their microenvironments and their capacity to regenerate organs. These projects are tied to ongoing research activities funded by grants with a view to regeneration of cells, formation of ectopic or artificial lymphoid tissues, and development of whole organs, like the spleen. Recent specific projects I am involved with include:
1. Characterisation, isolation and transplantation of hematopoietic stem cells
2. Investigation of perivascular reticular cells which form niches for tissue specific hematopoiesis
3. Role of the spleen in myelopoiesis
4. Development of retinal cells from pluripotent stem cells
Education/Academic qualification
Immunology, PhD, Australian National University
Award Date: 1 Jan 1981
Genetics, BSc Hons I, University of Adelaide
Administration, GD (Admin), University of Canberra
External positions
Emeritus Professor, Australian National University
Former Fellow, Stanford University
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Research Output
Advancing a stem cell therapy for age-related macular degeneration
O'Neill, H. C., Limnios, I. J. & Barnett, N. L., 2020, In : Current stem cell research & therapy. 15, 2, p. 89-97 9 p.Research output: Contribution to journal › Article › Research › peer-review
2
Citations
(Scopus)
A novel myeloid cell in murine spleen defined through gene profiling
Hey, Y. Y., O'Neill, T. & O'Neill, H. C., 1 Aug 2019, In : Journal of Cellular and Molecular Medicine. 23, 8, p. 5128-5143 16 p., 14382.Research output: Contribution to journal › Article › Research › peer-review
Open Access
File
Gene profiling murine splenic stromal lines: ArrayExpress Database Accession number E-MTAB-8345
O'Neill, H. C., Lim, D., Periasamy, P., Kumarappan, L., Tan, J. K. H. & O'Neill, T., 10 Oct 2019, European Bioinformatics Institute (EMBL-EBI).Research output: Other contribution › Research › peer-review
Open Access
Identification of stromal cells in spleen which support myelopoiesis
Lim, H. & O'Neill, H. C., 24 Jan 2019, In : Frontiers in Cell and Developmental Biology. 7, 1, 13 p., 425328.Research output: Contribution to journal › Article › Research › peer-review
Open Access
File
Targeting the Spleen as an Alternative Site for Hematopoiesis
Short, C., Lim, H., Tan, J. K. H. & O'Neill, H. C., May 2019, In : BioEssays. 41, 5, p. 1-9 9 p., 1800234.Research output: Contribution to journal › Article › Research › peer-review
Open Access
File
4
Citations
(Scopus)
300
Downloads
(Pure)