Research Output per year
Personal profile
Research interests
My research experience has been in the fields of immunology and experimental hematology and the development of hematopietic cells from stem cells.
My lab has developed new and exacting culture methods and stem cell isolation procedures that will form the basis of future work on stem cells and tissue regeneration. Recent important findings relate to hematopoiesis which occurs in spleen, and definition of myelopoiesis unique to spleen.
I have a particular interest in stromal cell microenvironments which support hematopoietic and mesenchymal stem cell development for tissue regeneration, and a long standing interest in lymphocyte and dendritic cell development and function.
Statement for HDR students
A range of student projects are available related to stem cells, their microenvironments and their capacity to regenerate organs. These projects are tied to ongoing research activities funded by grants with a view to regeneration of cells, formation of ectopic or artificial lymphoid tissues, and development of whole organs, like the spleen. Recent specific projects I am involved with include:
1. Characterisation, isolation and transplantation of hematopoietic stem cells
2. Investigation of perivascular reticular cells which form niches for tissue specific hematopoiesis
3. Role of the spleen in myelopoiesis
4. Development of retinal cells from pluripotent stem cells
Education/Academic qualification
Immunology, PhD, Australian National University
Genetics, BSc Hons I, University of Adelaide
Administration, GD (Admin), University of Canberra
External positions
Emeritus Professor, Australian National University
Former Fellow, Stanford University
Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.
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Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Research Output 1976 2019
Identification of stromal cells in spleen which support myelopoiesis
Lim, H. & O'Neill, H. C., 8 Jan 2019, (Accepted/In press) In : Frontiers in Cell and Developmental Biology. 7, 1, 425328.Research output: Contribution to journal › Article › Research › peer-review
Open Access
File
Myelopoiesis
Stromal Cells
Spleen
Hematopoiesis
Cell Fractionation
Identification of genes which regulate stroma-dependent in vitro hematopoiesis
Periasamy, P., Tran, V. & O'Neill, H. C., 11 Oct 2018, In : PLoS One. 13, 10, p. e0205583 20 p., e0205583.Research output: Contribution to journal › Article › Research › peer-review
Open Access
File
hematopoiesis
Hematopoiesis
Genes
coculture
Coculture Techniques
In vitro murine hematopoiesis supported by signaling from a splenic stromal cell line
Lim, H., Periasamy, P. & O'Neill, H., 25 Dec 2018, In : Stem Cells International. 2018, 9 p., 9896142.Research output: Contribution to journal › Article › Research › peer-review
Open Access
File
Hematopoiesis
Stromal Cells
Cell Line
Hematopoietic Stem Cells
Bone Marrow
MCSF drives regulatory DC development in stromal co-cultures supporting hematopoiesis
Petvises, S., Periasamy, P. & O'Neill, H. C., 26 Jun 2018, In : BMC Immunology. 19, 1, p. 21 21.Research output: Contribution to journal › Article › Research › peer-review
Open Access
File
Hematopoiesis
Coculture Techniques
Dendritic Cells
T-Lymphocytes
Macrophage Colony-Stimulating Factor
Spleen as a Site for Hematopoiesis
Lim, H. K. D., Tan, J. & O'Neill, H. C., 22 Aug 2018, In : Experimental Hematology. 64, Supplement, p. S80 1 p., 3091.Research output: Contribution to journal › Meeting Abstract › Research › peer-review
Hematopoiesis
Hematopoietic Stem Cells
Stromal Cells
Spleen
Stem Cell Niche
Press / Media
Bond receives multi-million dollar private donation to fund stem cell research
24/11/17 → 29/11/17
4 items of media coverage
Press/Media: Expert Comment
Bond University Research Week: Sharks, Stem Cells and Raw Milk Cheese.
Daryl McPhee, Helen O'Neill & William Van Caenegem
20/11/15
1 item of media coverage
Press/Media: Expert Comment
Uni lifts research
Helen O'Neill & Russell Chess-Williams
15/07/15
1 item of media coverage
Press/Media: Expert Comment
Bond expands medical research centre
Helen O'Neill & Russell Chess-Williams
14/07/15
2 items of media coverage
Press/Media: Expert Comment