Helen O'Neill

Prof, Director Clem Jones Centre for Regenerative Medicine, Cutmore Distinguished Professor of Stem Cell Research

  • Bond University, Faculty of Health Sciences and Medicine

    4229 Gold Coast

    Australia

Accepting PhD Students

  • 1852 Citations
  • 25 h-Index
1976 …2019
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Personal profile

Research interests

My research experience has been in the fields of immunology and experimental hematology and the development of hematopietic cells from stem cells.

My lab has developed new and exacting culture methods and stem cell isolation procedures that will form the basis of future work on stem cells and tissue regeneration. Recent important findings relate to hematopoiesis which occurs in spleen, and definition of myelopoiesis unique to spleen. 

I have a particular interest in stromal cell microenvironments which support hematopoietic and mesenchymal stem cell development for tissue regeneration, and a long standing interest in lymphocyte and dendritic cell development and function.

Statement for HDR students

A range of student projects are available related to stem cells, their microenvironments and their capacity to regenerate organs. These projects are tied to ongoing research activities funded by grants with a view to regeneration of cells, formation of ectopic or artificial lymphoid tissues, and development of whole organs, like the spleen. Recent specific projects I am involved with include: 

1. Characterisation, isolation and transplantation of hematopoietic stem cells 

2. Investigation of perivascular reticular cells which form niches for tissue specific hematopoiesis

3. Role of the spleen in myelopoiesis

4. Development of retinal cells from pluripotent stem cells

Education/Academic qualification

Immunology, PhD, Australian National University

Genetics, BSc Hons I, University of Adelaide

Administration, GD (Admin), University of Canberra

External positions

Emeritus Professor, Australian National University

Former Fellow, Stanford University

Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

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Dendritic Cells Medicine & Life Sciences
Spleen Medicine & Life Sciences
Hematopoiesis Medicine & Life Sciences
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T-Lymphocytes Medicine & Life Sciences
Hematopoietic Stem Cells Medicine & Life Sciences
Antigen-Presenting Cells Medicine & Life Sciences
Cell Line Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 1976 2019

Identification of stromal cells in spleen which support myelopoiesis

Lim, H. & O'Neill, H. C., 8 Jan 2019, (Accepted/In press) In : Frontiers in Cell and Developmental Biology. 7, 1, 425328.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Myelopoiesis
Stromal Cells
Spleen
Hematopoiesis
Cell Fractionation

Identification of genes which regulate stroma-dependent in vitro hematopoiesis

Periasamy, P., Tran, V. & O'Neill, H. C., 11 Oct 2018, In : PLoS One. 13, 10, p. e0205583 20 p., e0205583.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
hematopoiesis
Hematopoiesis
Genes
coculture
Coculture Techniques

In vitro murine hematopoiesis supported by signaling from a splenic stromal cell line

Lim, H., Periasamy, P. & O'Neill, H., 25 Dec 2018, In : Stem Cells International. 2018, 9 p., 9896142.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Hematopoiesis
Stromal Cells
Cell Line
Hematopoietic Stem Cells
Bone Marrow
1 Citation (Scopus)

MCSF drives regulatory DC development in stromal co-cultures supporting hematopoiesis

Petvises, S., Periasamy, P. & O'Neill, H. C., 26 Jun 2018, In : BMC Immunology. 19, 1, p. 21 21.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Hematopoiesis
Coculture Techniques
Dendritic Cells
T-Lymphocytes
Macrophage Colony-Stimulating Factor

Spleen as a Site for Hematopoiesis

Lim, H. K. D., Tan, J. & O'Neill, H. C., 22 Aug 2018, In : Experimental Hematology. 64, Supplement, p. S80 1 p., 3091.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Hematopoiesis
Hematopoietic Stem Cells
Stromal Cells
Spleen
Stem Cell Niche

Press / Media

Bond receives multi-million dollar private donation to fund stem cell research

Helen O'Neill

24/11/1729/11/17

4 items of media coverage

Press/Media: Expert Comment

Bond adds new chair in biology

Helen O'Neill

21/07/15

1 item of media coverage

Press/Media: Expert Comment

Uni lifts research

Helen O'Neill & Russell Chess-Williams

15/07/15

1 item of media coverage

Press/Media: Expert Comment

Bond expands medical research centre

Helen O'Neill & Russell Chess-Williams

14/07/15

2 items of media coverage

Press/Media: Expert Comment