Helen O'Neill

Prof, Director Clem Jones Centre for Regenerative Medicine, Cutmore Distinguished Professor of Stem Cell Research

  • Bond University, Faculty of Health Sciences and Medicine

    4229 Gold Coast


Accepting PhD Students

  • 1965 Citations
  • 26 h-Index
1976 …2019
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Personal profile

Research interests

My research experience has been in the fields of immunology and experimental hematology and the development of hematopietic cells from stem cells.

My lab has developed new and exacting culture methods and stem cell isolation procedures that will form the basis of future work on stem cells and tissue regeneration. Recent important findings relate to hematopoiesis which occurs in spleen, and definition of myelopoiesis unique to spleen. 

I have a particular interest in stromal cell microenvironments which support hematopoietic and mesenchymal stem cell development for tissue regeneration, and a long standing interest in lymphocyte and dendritic cell development and function.

Statement for HDR students

A range of student projects are available related to stem cells, their microenvironments and their capacity to regenerate organs. These projects are tied to ongoing research activities funded by grants with a view to regeneration of cells, formation of ectopic or artificial lymphoid tissues, and development of whole organs, like the spleen. Recent specific projects I am involved with include: 

1. Characterisation, isolation and transplantation of hematopoietic stem cells 

2. Investigation of perivascular reticular cells which form niches for tissue specific hematopoiesis

3. Role of the spleen in myelopoiesis

4. Development of retinal cells from pluripotent stem cells

Education/Academic qualification

Immunology, PhD, Australian National University

Genetics, BSc Hons I, University of Adelaide

Administration, GD (Admin), University of Canberra

External positions

Emeritus Professor, Australian National University

Former Fellow, Stanford University

Fingerprint Dive into the research topics where Helen O'Neill is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 4 Similar Profiles
Spleen Medicine & Life Sciences
Dendritic Cells Medicine & Life Sciences
Hematopoiesis Medicine & Life Sciences
Radiation Leukemia Virus Medicine & Life Sciences
T-Lymphocytes Medicine & Life Sciences
Hematopoietic Stem Cells Medicine & Life Sciences
Antigen-Presenting Cells Medicine & Life Sciences
Myeloid Cells Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 1976 2019

Advancing a stem cell therapy for age-related macular degeneration

O'Neill, H. C., Limnios, I. J. & Barnett, N. L., 17 Dec 2019, In : Current stem cell research & therapy.

Research output: Contribution to journalArticleResearchpeer-review

Retinal Pigment Epithelium
Macular Degeneration
Cell- and Tissue-Based Therapy
Stem Cells
Pluripotent Stem Cells
82 Downloads (Pure)

A novel myeloid cell in murine spleen defined through gene profiling

Hey, Y. Y., O'Neill, T. & O'Neill, H. C., 1 Aug 2019, In : Journal of Cellular and Molecular Medicine. 23, 8, p. 5128-5143 16 p., 14382.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
Myeloid Cells
Dendritic Cells

Gene profiling murine splenic stromal lines: ArrayExpress Database Accession number E-MTAB-8345

O'Neill, H. C., Lim, D., Periasamy, P., Kumarappan, L., Tan, J. K. H. & O'Neill, T., 10 Oct 2019, European Bioinformatics Institute (EMBL-EBI).

Research output: Other contributionResearchpeer-review

Open Access
Cell Lineage
Stromal Cells
46 Downloads (Pure)

Identification of stromal cells in spleen which support myelopoiesis

Lim, H. & O'Neill, H. C., 24 Jan 2019, In : Frontiers in Cell and Developmental Biology. 7, 1, 13 p., 425328.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
Stromal Cells
Cell Fractionation
1 Citation (Scopus)
174 Downloads (Pure)

Targeting the Spleen as an Alternative Site for Hematopoiesis

Short, C., Lim, H., Tan, J. K. H. & O'Neill, H. C., May 2019, In : BioEssays. 41, 5, p. 1-9 9 p., 1800234.

Research output: Contribution to journalArticleResearchpeer-review

Stem cells

Press / Media

Bond receives multi-million dollar private donation to fund stem cell research

Helen C O'Neill


4 items of Media coverage

Press/Media: Expert Comment

Bond adds new chair in biology

Helen Christine O'Neill


1 item of Media coverage

Press/Media: Expert Comment

Uni lifts research

Helen Christine O'Neill & Russ Chess-Williams


1 item of Media coverage

Press/Media: Expert Comment

Bond expands medical research centre

Helen Christine O'Neill & Russ Chess-Williams


2 items of Media coverage

Press/Media: Expert Comment