Personal profile
Research interests
My research interests are focussed on the physiology and pharmacology of the urogenital tract and cardiovascular system in health and disease, and in particular the mechanisms that underlie bladder dysfunction such as overactive bladder, which can lead to incontinence, as well as atherosclerosis and the complications of diabetes. The aim of this research is to increase our understanding of how these bodily systems function and are altered in disease, in order to aid the development of new or novel treatments, or enhance the effectiveness of currently available treatments.
I am a member of a number of professional organisations including the International Continence Society, European Association of Urology, British Pharmacological Society, Continence Health Australia and Australasian Society for Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT). I have served as chair and secretary of the ASCEPT Special Interest Group for Urogenital and Gastrointestinal Pharmacology, and have held positions on a number of external advisory boards.
I am a co-editor for Continence, the official journal of the International Continence Society, and have served as Associate Editor for Life Sciences, am a member of the Editorial Board for the Journal of Pharmacological and Toxicological Methods and BMC Urology, and a Review Editor for Frontiers in Pharmacology (Cardiovascular and Smooth Muscle Pharmacology) and Frontiers in Physiology (Clinical and Translational Physiology).
Statement for HDR students
HDR students are one of the most enjoyable aspects of my research. I have supervised 12 HDR students to successful completion, 7 as principal supervisor, 8 Honours research students to first class honours degrees and many other Masters Research students.
My past students have completed projects in a number of areas including pharmacology of the lower urinary tract, particularly with relation to stress urinary incontinence and faecal incontinence and ureteral (kidney) stones, and mechanisms to modulate smooth muscle tone in these conditions. Other projects include the physiology and pathophysiology of the steptozotocin-induced diabetic bladder, mechanisms underlying the development of atherosclerosis, pharmacological investigation of porcine bladder function and sensory activity, effects of low testosterone on bladder function and mechanisms linking erectile dysfunction and enlarged prostate. All of my past research students have gone on to have success in academia, research or industry.
I am currently supervising research students in the Centre for Urology Research. Contact me if you are interested in any of the above topics.
Education/Academic qualification
Learning & Teaching, Postgraduate Certificate, Sheffield Hallam University
Award Date: 1 Nov 2002
Medicine, PhD, The effects of diabetes mellitus on the cardiovascular system., University of Sheffield
Award Date: 30 Jul 1997
Anatomy & Cell Biology, BSc. (Hons first class), University of Sheffield
Award Date: 1 Jul 1989
External positions
Sheffield Hallam University
2001 → 31 Dec 2009
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
-
SDG 3 Good Health and Well-being
Fingerprint
- 1 Similar Profiles
Collaborations and top research areas from the last five years
-
A feasibility study of the repurposing of prazosin to improve treatment outcomes in men receiving radiotherapy for prostate cancer (MiniRaP-00)
King, L. D., Christie, D., Cehic, D., Dare, W., Chess-Williams, R., Sellers, D., McDermott, C., McCarthy, A. & Anoopkumar-Dukie, S., Jun 2026, In: The Prostate. 86, 8, p. 891-899 9 p.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile5 Downloads (Pure) -
Inhibition of PDE‑4 and PDE‑5 Differentially Modulates Isolated Porcine Urethral Contractility
Burovski, E., Sellers, D. J., Chess-Williams, R. & Lim, I., 13 Mar 2025, In: International Urogynecology Journal. 36, 9, p. 1767-1773 7 p.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile34 Downloads (Pure) -
Measurement of Oxidative Stress to Allow the Development and Use of New Therapies in Lower Urinary Tract Dysfunction: Ici-rs 2025
Tarcan, T., Vahabi, B., Mosiello, G., Fry, C., Tyagi, P., Sellers, D., Lombardo, R., Wein, A., Abrams, P. & Kanai, A., 11 Nov 2025, (E-pub ahead of print) In: Neurourology and Urodynamics.Research output: Contribution to journal › Review article › Research › peer-review
1 Link opens in a new tab Citation (Scopus) -
Inhibition of PDE-4 isoenzyme attenuates frequency and overall contractility of agonist-evoked ureteral phasic contractions
Lim, I., Masutani, T., Hashitani, H., Chess-Williams, R. & Sellers, D. J., Feb 2024, In: Pharmacology Research and Perspectives. 12, 1, p. 1-9 9 p., e1175.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile3 Link opens in a new tab Citations (Scopus)138 Downloads (Pure) -
Natural products for the treatment of urinary incontinence
Chess-Williams, R., Mansfield, K., Exintaris, B., Lim, I. & Sellers, D. J., Sept 2023, In: Continence. 7, p. 1-6 6 p., 100714.Research output: Contribution to journal › Review article › Research › peer-review
Open AccessFile297 Downloads (Pure)
Activities
-
Functional changes in the bladder in a preclinical model of perimenopause
Sellers, D. (Speaker)
15 May 2026Activity: Talk or presentation › Invited talk
-
Pharmacology (Journal)
Sellers, D. (Member of editorial board)
2025Activity: Publication peer-review and editorial work › Editorial Board Member
-
The bioactivity of cannabis phytochemicals for antimicrobial activity, gastrointestinal and urological protection
Sellers, D. (Examiner)
Sept 2025 → …Activity: Examination › Thesis Examination
-
International Consultation on Incontinence Research Society
Sellers, D. (Panelist)
5 Jun 2025 → 7 Jun 2025Activity: Participating in or organising an event › Participating in a conference, workshop, ... › Oral Presentation
-
BMC Urology (Journal)
Sellers, D. (Member of editorial board)
Oct 2025 → …Activity: Publication peer-review and editorial work › Peer-review