Research Output per year
Personal profile
Research interests
My research interests are focussed on the physiology and pharmacology of the urogenital tract and cardiovascular system in health and disease, and in particular the mechanisms that underlie bladder dysfunction such as overactive bladder, which can lead to incontinence, as well as atherosclerosis and the complications of diabetes. The aim of this research is to increase our understanding of how these bodily systems function and are altered in disease, in order to aid the development of new or novel treatments, or enhance the effectiveness of currently available treatments.
I am a member of a number of professional organisations including the International Continence Society, European Association of Urology, British Pharmacological Society, Continence Foundation of Australia and Australasian Society for Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT). I am also the current secretary of the ASCEPT Special Interest Group for Urogenital and Gastrointestinal Research, which I have previously co-chaired.
I have served as Associate Editor for Life Sciences, am a member of the Editorial Board for the Journal of Pharmacological and Toxicological Methods and a Review Editor for Frontiers in Pharmacology (Cardiovascular and Smooth Muscle Pharmacology) and Frontiers in Physiology (Clinical and Translational Physiology).
Statement for HDR students
HDR students are one of the most enjoyable aspects of my research. I have supervised 5 PhD students to successful completion as principal supervisor, an additional 3 PhD students as co-supervisor, 4 Honours research students to first class honours degrees and many other Masters Research students.
My past students have completed projects in a number of areas including pharmacology of the lower urinary tract, particularly with relation to stress urinary incontinence and faecal incontinence and ureteral (kidney) stones,and mechanisms to modulate smooth muscle tone in these conditions. Other projects include the physiology and pathophysiology of the steptozotocin-induced diabetic rat bladder, mechanisms underlying the development of atherosclerosis, pharmacological investigation of porcine bladder function and sensory activity, effects of low testosterone on bladder function and mechanisms linking erectile dysfunction and enlarged prostate. Nearly all of my past students now work in academia or research.
Along with Russ Chess-Williams and Catherine McDermott I am currently supervising 3 PhD students in the Centre for Urology Research. Contact us if you are interested in any of the above topics.
Education/Academic qualification
Learning & Teaching, Postgraduate Certificate, Sheffield Hallam University
Medicine, PhD, University of Sheffield
Anatomy & Cell Biology, BSc. (Hons first class), University of Sheffield
External positions
Sheffield Hallam University
2001 → 31 Dec 2009Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.
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Research Output 1994 2018
5-HT2A receptor is the predominant receptor mediating contraction of the isolated porcine distal ureter to 5-HT in young and old animals
Lim, I., Chess-Williams, R. & Sellers, D., 5 Jan 2018, In : European Journal of Pharmacology. 818, p. 328-334 7 p.Research output: Contribution to journal › Article › Research › peer-review
A central role for toll-like 4 (TLR4) receptors in interstitial cystitis?
Sellers, D. J., McDermott, C. & Chess-Williams, R., 27 Jun 2018, In : American Journal of Physiology - Renal Physiology.Research output: Contribution to journal › Article › Research › peer-review
Altered ureteral contractility with ageing: Role of the rho-kinase pathway
Lim, I., Chess-Williams, R. & Sellers, D., 1 Apr 2018, In : Mechanisms of Ageing and Development. 171, p. 31-36 6 p.Research output: Contribution to journal › Article › Research › peer-review
Diabetes-induced alterations in urothelium function: Enhanced ATP release and nerve-evoked contractions in the streptozotocin rat bladder
Lee, S., Rose'meyer, R., McDermott, C., Chess-Williams, R. & Sellers, D. J., 1 Nov 2018, In : Clinical and Experimental Pharmacology and Physiology. 45, 11, p. 1161-1169 9 p.Research output: Contribution to journal › Article › Research › peer-review
Ibuprofen decreases spontaneous activity and enhances nerve-evoked contractions to minimize mitomycin c-induced bladder dysfunction
West, E. G., Lang, R., Sellers, D., Chess-Williams, R. & McDermott, C., 1 Aug 2018, In : Journal of Pharmacology and Experimental Therapeutics. 366, 2, p. 282-290 9 p.Research output: Contribution to journal › Article › Research › peer-review
Activities 2019 2019
- 1 Internal Professional Development
Bond University HDR Support Series 191: Session 5
Jo-Anne Johnson (Organiser), Donna J Sellers (Presenter), Rebecca Sims (Attendee), Russell Mills (Attendee), Daniel Shabrokh (Attendee), Minori Watanabe (Organiser), Tarisa Yasin (Attendee), Caleb Kam (Attendee), Hyo Jeong Kim (Attendee), Rani West (Attendee), Gyan Wijekulasuriya (Attendee), Dipanwita Bhattacharjee (Attendee), Robyn McCormack (Attendee), Sue Manchoulas (Attendee), Simrata Nand (Attendee), Daniel Maupin (Attendee), Daniel Shabrokh (Attendee)Activity: Professional Development › Internal Professional Development › Attending at professional training session
Student theses
Contractile activity of the bladder urothelium and lamina propria
Author: Moro, C., 9 Feb 2013Supervisor: Chess-Williams, R. (Supervisor) & Sellers, D. J. (Supervisor)
Student thesis: Doctoral Thesis
Drug targets for urinary and faecal incontinence and anal fissure
Author: Folasire, O., 11 Feb 2017Supervisor: Sellers, D. J. (Supervisor) & Chess-Williams, R. G. (Supervisor)
Student thesis: Doctoral Thesis
Mechanisms controlling ureteral motility
Author: Lim, I., 11 Feb 2017Supervisor: Sellers, D. J. (Supervisor) & Chess-Williams, R. G. (Supervisor)
Student thesis: Doctoral Thesis
Non-Neuronal ATP: Regulation of Release and Action in the Bladder
Author: Grundy, L., 11 Oct 2014Supervisor: Chess-Williams, R. G. (Supervisor) & Sellers, D. J. (Supervisor)
Student thesis: Doctoral Thesis