Catherine McDermott — Bond University Research Portal

Personal profile

Research interests

I completed my Bachelor of Science (Physiology) and PhD at University College in Cork, Ireland, before moving to Australia in 2008.

I have conducted extensive research, with a particular focus on sub-chronic toxicity of organic solvent mixtures in vitro, and also the effects of chemotherapeutic agents on normal bladder function.

As a university lecturer/researcher, I combine a clear understanding of the teaching and learning process with in-depth subject knowledge informed by my own studies and research.

Many bladder cancer patients experience local side-effects following chemotherapy which greatly affect patient quality of life and ability to tolerate treatment. One of my main research interests is to try to understand why these side-effects occur by investigating the effects of chemotherapeutic drugs on normal bladder function. To do this we use in vitro models of the human urothelium. Through these studies we also aim to assess the ability of the urothelium to recover following treatment and determine if there are other drugs that could be used to treat bladder cancer that would be more effective and more tolerable.

Statement for HDR students

These are some of the current HDR projects and students I supervise:

Cytotoxic drugs and their effects on bladder function - PhD student - Stanley Kang
Cyclophosphamide and Ifosfamide: Mechanisms of urotoxicity and consequences for normal bladder function - PhD student - Kylie Mills
Quinazoline based alpha 1-adrenoceptor antagonists and prostate cancer - PhD student - Amanda Forbes
Interactions between urothelial mediators regulating release from cultured urothelial cells and porcine urothelial tissue - PhD student - Katrina Smith

Education/Academic qualification

PhD

Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

Pyocyanine Medicine & Life Sciences

Toxicity Chemical Compounds

Urinary Bladder Medicine & Life Sciences

Urothelium Medicine & Life Sciences

Adenosine Triphosphate Medicine & Life Sciences

docetaxel Medicine & Life Sciences

Dinoprostone Medicine & Life Sciences

gemcitabine Medicine & Life Sciences

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Research Output 2007 2018

2664 Citations
12 h-Index
26 Article
13 Meeting Abstract
3 Abstract
3 Review article
1 More
- 1 Conference contribution

A central role for toll-like 4 (TLR4) receptors in interstitial cystitis?

Sellers, D. J., McDermott, C. & Chess-Williams, R., 27 Jun 2018, In : American Journal of Physiology - Renal Physiology.

Research output: Contribution to journal › Article › Research › peer-review

Interstitial Cystitis

Toll-Like Receptor 4

Urinary Bladder

Pain

Anxiety

Diabetes-induced alterations in urothelium function: Enhanced ATP release and nerve-evoked contractions in the streptozotocin rat bladder

Lee, S., Rose'meyer, R., McDermott, C., Chess-Williams, R. & Sellers, D. J., 1 Nov 2018, In : Clinical and Experimental Pharmacology and Physiology. 45, 11, p. 1161-1169 9 p.

Research output: Contribution to journal › Article › Research › peer-review

Urothelium

Streptozocin

Urinary Bladder

Adenosine Triphosphate

Compliance

2 Citations (Scopus)

Differences in statin associated neuroprotection corresponds with either decreased production of IL-1β or TNF-α in an in vitro model of neuroinflammation-induced neurodegeneration

McFarland, A. J., Davey, A. K., McDermott, C. M., Grant, G. D., Lewohl, J. & Anoopkumar-Dukie, S., 1 Apr 2018, In : Toxicology and Applied Pharmacology. 344, p. 56-73 18 p.

Research output: Contribution to journal › Article › Research › peer-review

Hydroxymethylglutaryl-CoA Reductase Inhibitors

Interleukin-1

Pravastatin

Neurology

Lipopolysaccharides

Ibuprofen decreases spontaneous activity and enhances nerve-evoked contractions to minimize mitomycin c-induced bladder dysfunction

West, E. G., Lang, R., Sellers, D., Chess-Williams, R. & McDermott, C., 1 Aug 2018, In : Journal of Pharmacology and Experimental Therapeutics. 366, 2, p. 282-290 9 p.

Research output: Contribution to journal › Article › Research › peer-review

Ibuprofen

Mitomycin

Urinary Bladder

Caspase 3

Inbred C57BL Mouse

1 Citation (Scopus)

Prazosin but Not Tamsulosin Sensitises PC-3 and LNCaP Prostate Cancer Cells to Docetaxel

Spencer, B. H., McDermott, C. M., Chess-Williams, R., Christie, D. & Anoopkumar-Dukie, S., 1 Aug 2018, In : Pharmacology. 102, 1-2, p. 17-25 9 p.

Research output: Contribution to journal › Article › Research › peer-review

tamsulosin

docetaxel

Prazosin

Prostatic Neoplasms

Quinazolines

Activities 2016 2017

1 Organising a conference, workshop, ...
1 Internal memberships, committees, boards and panelists

9th National Symposium on Advances in Gastrointestinal & Urogenital Research

Catherine McDermott (Organiser)

4 Dec 2017

Activity: Participating in or organising an event › Organising a conference, workshop, ...

Bond University Sage Athena Swan Self-Assessment Team (External organisation)

Linda H Crane (Chair), Andrew Calder (Member), Barry Burgan (Member), Catherine McDermott (Member), Christopher Andrews (Member), Duane Kelaart (Member), Gary Brady (Member), Keitha Dunstan (Member), Kenneth Richardson (Member), Michelle Markham (Member), Tanya Forbes (Member), Donna F. Henson (Member), Ray N Moynihan (Member)

1 Oct 2016 → 31 Mar 2019

Activity: Membership › Internal memberships, committees, boards and panelists