Photo of Catherine McDermott
  • Bond University, Faculty of Health Sciences and Medicine

    4229 Gold Coast

    Australia

  • 2886 Citations
  • 13 h-Index
20072020

Research output per year

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Personal profile

Research interests

I completed my Bachelor of Science (Physiology) and PhD at University College in Cork, Ireland, before moving to Australia in 2008.

I have conducted extensive research, with a particular focus on sub-chronic toxicity of organic solvent mixtures in vitro, and also the effects of chemotherapeutic agents on normal bladder function.

As a university lecturer/researcher, I combine a clear understanding of the teaching and learning process with in-depth subject knowledge informed by my own studies and research.

Many bladder cancer patients experience local side-effects following chemotherapy which greatly affect patient quality of life and ability to tolerate treatment. One of my main research interests is to try to understand why these side-effects occur by investigating the effects of chemotherapeutic drugs on normal bladder function. To do this we use in vitro models of the human urothelium. Through these studies we also aim to assess the ability of the urothelium to recover following treatment and determine if there are other drugs that could be used to treat bladder cancer that would be more effective and more tolerable.

Statement for HDR students

These are some of the current HDR projects and students I supervise:

  • Cytotoxic drugs and their effects on bladder function - PhD student - Stanley Kang
  • Cyclophosphamide and Ifosfamide: Mechanisms of urotoxicity and consequences for normal bladder function - PhD student - Kylie Mills
  • Quinazoline based alpha 1-adrenoceptor antagonists and prostate cancer - PhD student - Amanda Forbes
  • Interactions between urothelial mediators regulating release from cultured urothelial cells and porcine urothelial tissue - PhD student - Katrina Smith

 

Education/Academic qualification

PhD

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Research Output

The COX-2 inhibitor NS398 selectively sensitizes hypoxic HeLa cells to ionising radiation by mechanisms both dependent and independent of COX-2

Anoopkumar-Dukie, S., Conere, T., Houston, A., King, L., Christie, D., McDermott, C. & Allshire, A., 28 Jan 2020, In : Journal of Lipid Mediators and Cell Signalling. 148, 106422.

Research output: Contribution to journalArticleResearchpeer-review

  • Acrolein, the toxic urinary metabolite of cyclophosphamide, causes physiological changes to bladder function

    Sellers, D. J., Chess-Williams, R., McDermott, C. & West, E., 2019, In : Australian and New Zealand Continence Journal. 25, 4, p. 96-97 2 p.

    Research output: Contribution to journalMeeting AbstractResearchpeer-review

  • Elevated release of inflammatory but not sensory mediators from the urothelium is maintained following epirubicin treatment

    Kang, S. H., Chess-Williams, R. & McDermott, C., 15 Nov 2019, In : European Journal of Pharmacology. 863, 9 p., 172703.

    Research output: Contribution to journalArticleResearchpeer-review

  • Emotional versus physical stress in mice: Impact on bladder function

    West, E., Sellers, D. J., Chess-Williams, R. & McDermott, C., 2019, In : Australian and New Zealand Continence Journal. 25, 4, p. 95-96 2 p.

    Research output: Contribution to journalMeeting AbstractResearchpeer-review

  • Novel insights into the mechanism of cyclophosphamide-induced bladder toxicity: chloroacetaldehyde's contribution to urothelial dysfunction in vitro

    Mills, K. A., Chess-Williams, R. & McDermott, C., 1 Nov 2019, In : Archives of Toxicology. 93, 11, p. 3291-3303 13 p.

    Research output: Contribution to journalArticleResearchpeer-review

  • Activities

    • 1 Organising a conference, workshop, ...
    • 1 Internal memberships, committees, boards and panelists

    9th National Symposium on Advances in Gastrointestinal & Urogenital Research

    Catherine McDermott (Organiser)
    4 Dec 2017

    Activity: Participating in or organising an eventOrganising a conference, workshop, ...

    Bond University Sage Athena Swan Self-Assessment Team (External organisation)

    Linda H Crane (Chair), Andrew Calder (Member), Barry Burgan (Member), Catherine McDermott (Member), Christopher Andrews (Member), Duane Kelaart (Member), Gary Brady (Member), Keitha Dunstan (Member), Kenneth Richardson (Member), Michelle Markham (Member), Tanya Forbes (Member), Donna F. Henson (Member), Ray N Moynihan (Member)
    1 Oct 201631 Mar 2019

    Activity: MembershipInternal memberships, committees, boards and panelists

    Student theses

    Cyclophosphamide and ifosfamide: mechanisms of cytotoxic action and consequences for normal bladder function

    Author: Mills, K., 10 Oct 2015

    Supervisor: Chess-Williams, R. G. (Supervisor) & McDermott, C. (Supervisor)

    Student thesis: Doctoral Thesis

    File

    Cytotoxic Drugs and their Effects on Bladder Function

    Author: Kang, S. H., 10 Oct 2015

    Supervisor: McDermott, C. (Supervisor) & Chess-Williams, R. G. (Supervisor)

    Student thesis: Doctoral Thesis

    File

    Intravesical gemcitabine treatment: repercussions on normal bladder function.

    Author: Farr, S., 2015

    Supervisor: McDermott, C. (Supervisor) & Chess-Williams, R. G. (Supervisor)

    Student thesis: Doctoral Thesis

    File

    Quinazoline-based Alpha1-Adrenoceptor Antagonists and Prostate Cancer

    Author: Forbes, A., 8 Oct 2016

    Supervisor: McDermott, C. (Supervisor), Chess-Williams, R. (Supervisor) & Anoopkumar-Dukie, S. (External person) (Supervisor)

    Student thesis: Doctoral Thesis

    File

    The impact of intravesical treatments for bladder pain syndrome on normal bladder function.

    Author: Smith, K., 2019

    Supervisor: Chess-Williams, R. G. (Supervisor) & McDermott, C. (Supervisor)

    Student thesis: Doctoral Thesis

    File