Research Output per year
Personal profile
Research interests
I completed my Bachelor of Science (Physiology) and PhD at University College in Cork, Ireland, before moving to Australia in 2008.
I have conducted extensive research, with a particular focus on sub-chronic toxicity of organic solvent mixtures in vitro, and also the effects of chemotherapeutic agents on normal bladder function.
As a university lecturer/researcher, I combine a clear understanding of the teaching and learning process with in-depth subject knowledge informed by my own studies and research.
Many bladder cancer patients experience local side-effects following chemotherapy which greatly affect patient quality of life and ability to tolerate treatment. One of my main research interests is to try to understand why these side-effects occur by investigating the effects of chemotherapeutic drugs on normal bladder function. To do this we use in vitro models of the human urothelium. Through these studies we also aim to assess the ability of the urothelium to recover following treatment and determine if there are other drugs that could be used to treat bladder cancer that would be more effective and more tolerable.
Statement for HDR students
These are some of the current HDR projects and students I supervise:
- Cytotoxic drugs and their effects on bladder function - PhD student - Stanley Kang
- Cyclophosphamide and Ifosfamide: Mechanisms of urotoxicity and consequences for normal bladder function - PhD student - Kylie Mills
- Quinazoline based alpha 1-adrenoceptor antagonists and prostate cancer - PhD student - Amanda Forbes
- Interactions between urothelial mediators regulating release from cultured urothelial cells and porcine urothelial tissue - PhD student - Katrina Smith
Education/Academic qualification
PhD
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Research Output
The COX-2 inhibitor NS398 selectively sensitizes hypoxic HeLa cells to ionising radiation by mechanisms both dependent and independent of COX-2
Anoopkumar-Dukie, S., Conere, T., Houston, A., King, L., Christie, D., McDermott, C. & Allshire, A., 28 Jan 2020, In : Journal of Lipid Mediators and Cell Signalling. 148, 106422.Research output: Contribution to journal › Article › Research › peer-review
Acrolein, the toxic urinary metabolite of cyclophosphamide, causes physiological changes to bladder function
Sellers, D. J., Chess-Williams, R., McDermott, C. & West, E., 2019, In : Australian and New Zealand Continence Journal. 25, 4, p. 96-97 2 p.Research output: Contribution to journal › Meeting Abstract › Research › peer-review
Elevated release of inflammatory but not sensory mediators from the urothelium is maintained following epirubicin treatment
Kang, S. H., Chess-Williams, R. & McDermott, C., 15 Nov 2019, In : European Journal of Pharmacology. 863, 9 p., 172703.Research output: Contribution to journal › Article › Research › peer-review
Emotional versus physical stress in mice: Impact on bladder function
West, E., Sellers, D. J., Chess-Williams, R. & McDermott, C., 2019, In : Australian and New Zealand Continence Journal. 25, 4, p. 95-96 2 p.Research output: Contribution to journal › Meeting Abstract › Research › peer-review
Novel insights into the mechanism of cyclophosphamide-induced bladder toxicity: chloroacetaldehyde's contribution to urothelial dysfunction in vitro
Mills, K. A., Chess-Williams, R. & McDermott, C., 1 Nov 2019, In : Archives of Toxicology. 93, 11, p. 3291-3303 13 p.Research output: Contribution to journal › Article › Research › peer-review
Activities
9th National Symposium on Advances in Gastrointestinal & Urogenital Research
Catherine McDermott (Organiser)4 Dec 2017
Activity: Participating in or organising an event › Organising a conference, workshop, ...
Bond University Sage Athena Swan Self-Assessment Team (External organisation)
Linda H Crane (Chair), Andrew Calder (Member), Barry Burgan (Member), Catherine McDermott (Member), Christopher Andrews (Member), Duane Kelaart (Member), Gary Brady (Member), Keitha Dunstan (Member), Kenneth Richardson (Member), Michelle Markham (Member), Tanya Forbes (Member), Donna F. Henson (Member), Ray N Moynihan (Member)1 Oct 2016 → 31 Mar 2019
Activity: Membership › Internal memberships, committees, boards and panelists
Student theses
Cyclophosphamide and ifosfamide: mechanisms of cytotoxic action and consequences for normal bladder function
Author: Mills, K., 10 Oct 2015Supervisor: Chess-Williams, R. G. (Supervisor) & McDermott, C. (Supervisor)
Student thesis: Doctoral Thesis
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Cytotoxic Drugs and their Effects on Bladder Function
Author: Kang, S. H., 10 Oct 2015Supervisor: McDermott, C. (Supervisor) & Chess-Williams, R. G. (Supervisor)
Student thesis: Doctoral Thesis
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Intravesical gemcitabine treatment: repercussions on normal bladder function.
Author: Farr, S., 2015Supervisor: McDermott, C. (Supervisor) & Chess-Williams, R. G. (Supervisor)
Student thesis: Doctoral Thesis
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Quinazoline-based Alpha1-Adrenoceptor Antagonists and Prostate Cancer
Author: Forbes, A., 8 Oct 2016Supervisor: McDermott, C. (Supervisor), Chess-Williams, R. (Supervisor) & Anoopkumar-Dukie, S. (External person) (Supervisor)
Student thesis: Doctoral Thesis
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The impact of intravesical treatments for bladder pain syndrome on normal bladder function.
Author: Smith, K., 2019Supervisor: Chess-Williams, R. G. (Supervisor) & McDermott, C. (Supervisor)
Student thesis: Doctoral Thesis
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