• Bond University, Faculty of Health Sciences and Medicine

    4229 Gold Coast

    Australia

  • 2583 Citations
  • 12 h-Index
20072018
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Personal profile

Research interests

I completed my Bachelor of Science (Physiology) and PhD at University College in Cork, Ireland, before moving to Australia in 2008.

I have conducted extensive research, with a particular focus on sub-chronic toxicity of organic solvent mixtures in vitro, and also the effects of chemotherapeutic agents on normal bladder function.

As a university lecturer/researcher, I combine a clear understanding of the teaching and learning process with in-depth subject knowledge informed by my own studies and research.

Many bladder cancer patients experience local side-effects following chemotherapy which greatly affect patient quality of life and ability to tolerate treatment. One of my main research interests is to try to understand why these side-effects occur by investigating the effects of chemotherapeutic drugs on normal bladder function. To do this we use in vitro models of the human urothelium. Through these studies we also aim to assess the ability of the urothelium to recover following treatment and determine if there are other drugs that could be used to treat bladder cancer that would be more effective and more tolerable.

Statement for HDR students

These are some of the current HDR projects and students I supervise:

  • Cytotoxic drugs and their effects on bladder function - PhD student - Stanley Kang
  • Cyclophosphamide and Ifosfamide: Mechanisms of urotoxicity and consequences for normal bladder function - PhD student - Kylie Mills
  • Quinazoline based alpha 1-adrenoceptor antagonists and prostate cancer - PhD student - Amanda Forbes
  • Interactions between urothelial mediators regulating release from cultured urothelial cells and porcine urothelial tissue - PhD student - Katrina Smith

 

Education/Academic qualification

PhD

Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

Pyocyanine Medicine & Life Sciences
Toxicity Chemical Compounds
Urinary Bladder Medicine & Life Sciences
Urothelium Medicine & Life Sciences
Adenosine Triphosphate Medicine & Life Sciences
docetaxel Medicine & Life Sciences
Dinoprostone Medicine & Life Sciences
gemcitabine Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 2007 2018

Interstitial Cystitis
Toll-Like Receptor 4
Urinary Bladder
Pain
Anxiety
Urothelium
Streptozocin
Urinary Bladder
Adenosine Triphosphate
Compliance
1 Citations

Differences in statin associated neuroprotection corresponds with either decreased production of IL-1β or TNF-α in an in vitro model of neuroinflammation-induced neurodegeneration

McFarland, A. J., Davey, A. K., McDermott, C. M., Grant, G. D., Lewohl, J. & Anoopkumar-Dukie, S., 1 Apr 2018, In : Toxicology and Applied Pharmacology. 344, p. 56-73 18 p.

Research output: Contribution to journalArticleResearchpeer-review

Hydroxymethylglutaryl-CoA Reductase Inhibitors
Tumor Necrosis Factor-alpha
Pravastatin
Neurology
Lipopolysaccharides
Ibuprofen
Mitomycin
Urinary Bladder
Caspase 3
Inbred C57BL Mouse
1 Citations

Prazosin but Not Tamsulosin Sensitises PC-3 and LNCaP Prostate Cancer Cells to Docetaxel

Spencer, B. H., McDermott, C. M., Chess-Williams, R., Christie, D. & Anoopkumar-Dukie, S., 1 Aug 2018, In : Pharmacology. 102, 1-2, p. 17-25 9 p.

Research output: Contribution to journalArticleResearchpeer-review

tamsulosin
docetaxel
Prazosin
Prostatic Neoplasms
Quinazolines

Activities 2016 2017

  • 1 Organising a conference, workshop, ...
  • 1 Internal memberships, committees, boards and panelists

9th National Symposium on Advances in Gastrointestinal & Urogenital Research

Catherine McDermott (Organiser)
4 Dec 2017

Activity: Participating in or organising an eventOrganising a conference, workshop, ...

Bond University Sage Athena Swan Self-Assessment Team (External organisation)

Linda H Crane (Chair), Andrew Calder (Member), Barry Burgan (Member), Catherine McDermott (Member), Christopher Andrews (Member), Duane Kelaart (Member), Gary Brady (Member), Keitha Dunstan (Member), Kenneth Richardson (Member), Michelle Markham (Member), Tanya Forbes (Member), Donna F. Henson (Member), Ray N Moynihan (Member)
1 Oct 201631 Mar 2019

Activity: MembershipInternal memberships, committees, boards and panelists

Student theses

Cyclophosphamide and ifosfamide: mechanisms of cytotoxic action and consequences for normal bladder function

Author: Mills, K., 10 Oct 2015

Supervisor: Chess-Williams, R. G. (Supervisor) & McDermott, C. (Supervisor)

Student thesis: Doctoral Thesis

File

Cytotoxic Drugs and their Effects on Bladder Function

Author: Kang, S. H., 10 Oct 2015

Supervisor: McDermott, C. (Supervisor) & Chess-Williams, R. G. (Supervisor)

Student thesis: Doctoral Thesis

File

Intravesical gemcitabine treatment: repercussions on normal bladder function.

Author: Farr, S., 2015

Supervisor: McDermott, C. (Supervisor) & Chess-Williams, R. (Supervisor)

Student thesis: Doctoral Thesis

File

Quinazoline-based Alpha1-Adrenoceptor Antagonists and Prostate Cancer

Author: Forbes, A., 8 Oct 2016

Supervisor: McDermott, C. (Supervisor), Chess-Williams, R. (Supervisor) & Anoopkumar-Dukie, S. (External person) (Supervisor)

Student thesis: Doctoral Thesis

File