Catherine McDermott

Personal profile

Research interests

I completed my Bachelor of Science (Physiology) and PhD at University College in Cork, Ireland, before moving to Australia in 2008.

I have conducted extensive research, with a particular focus on sub-chronic toxicity of organic solvent mixtures in vitro, and also the effects of chemotherapeutic agents on normal bladder function.

As a university lecturer/researcher, I combine a clear understanding of the teaching and learning process with in-depth subject knowledge informed by my own studies and research.

Many bladder cancer patients experience local side-effects following chemotherapy which greatly affect patient quality of life and ability to tolerate treatment. One of my main research interests is to try to understand why these side-effects occur by investigating the effects of chemotherapeutic drugs on normal bladder function. To do this we use in vitro models of the human urothelium. Through these studies we also aim to assess the ability of the urothelium to recover following treatment and determine if there are other drugs that could be used to treat bladder cancer that would be more effective and more tolerable.

Statement for HDR students

These are some of the current HDR projects and students I supervise:

Cytotoxic drugs and their effects on bladder function - PhD student - Stanley Kang
Cyclophosphamide and Ifosfamide: Mechanisms of urotoxicity and consequences for normal bladder function - PhD student - Kylie Mills
Quinazoline based alpha 1-adrenoceptor antagonists and prostate cancer - PhD student - Amanda Forbes
Interactions between urothelial mediators regulating release from cultured urothelial cells and porcine urothelial tissue - PhD student - Katrina Smith

Education/Academic qualification

PhD

Fingerprint Dive into the research topics where Catherine McDermott is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

Urinary Bladder Medicine & Life Sciences

Pyocyanine Medicine & Life Sciences

Toxicity Chemical Compounds

Urothelium Medicine & Life Sciences

Adenosine Triphosphate Medicine & Life Sciences

Dinoprostone Medicine & Life Sciences

docetaxel Medicine & Life Sciences

Acetylcholine Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 2007 2019

2837 Citations
12 h-Index
28 Article
16 Meeting Abstract
3 Abstract
3 Review article
1 More
- 1 Conference contribution

Acrolein, the toxic urinary metabolite of cyclophosphamide, causes physiological changes to bladder function

Sellers, D. J., Chess-Williams, R., McDermott, C. & West, E., 2019, In : Australian and New Zealand Continence Journal. 25, 4, p. 96-97 2 p.

Research output: Contribution to journal › Meeting Abstract › Research › peer-review

Acrolein

Poisons

Cyclophosphamide

Urinary Bladder

Purinergic Agonists

Elevated release of inflammatory but not sensory mediators from the urothelium is maintained following epirubicin treatment

Kang, S. H., Chess-Williams, R. & McDermott, C., 15 Nov 2019, In : European Journal of Pharmacology. 863, 9 p., 172703.

Research output: Contribution to journal › Article › Research › peer-review

Urothelium

Epirubicin

Cytokines

Acetylcholine

Interleukin-8

Emotional versus physical stress in mice: Impact on bladder function

West, E., Sellers, D. J., Chess-Williams, R. & McDermott, C., 2019, In : Australian and New Zealand Continence Journal. 25, 4, p. 95-96 2 p.

Research output: Contribution to journal › Meeting Abstract › Research › peer-review

Urinary Bladder

Psychological Stress

Wounds and Injuries

Purinergic Agonists

Corticosterone

Novel insights into the mechanism of cyclophosphamide-induced bladder toxicity: chloroacetaldehyde's contribution to urothelial dysfunction in vitro

Mills, K. A., Chess-Williams, R. & McDermott, C., 1 Nov 2019, In : Archives of Toxicology. 93, 11, p. 3291-3303 13 p.

Research output: Contribution to journal › Article › Research › peer-review

Acrolein

Cyclophosphamide

Toxicity

Acetylcysteine

Urinary Bladder

Psychological stress and recovery: compensation to overcome bladder overactivity in mice

West, E., Chess-Williams, R., Sellers, D. J. & McDermott, C., 2019, In : Australian and New Zealand Continence Journal. 25, 4, p. 93-94 2 p.

Research output: Contribution to journal › Meeting Abstract › Research › peer-review

Psychological Stress

Urinary Bladder

Overactive Urinary Bladder

Environmental Exposure

Phenotype

Activities 2016 2017

1 Organising a conference, workshop, ...
1 Internal memberships, committees, boards and panelists

9th National Symposium on Advances in Gastrointestinal & Urogenital Research

Catherine McDermott (Organiser)

4 Dec 2017

Activity: Participating in or organising an event › Organising a conference, workshop, ...

Bond University Sage Athena Swan Self-Assessment Team (External organisation)

Linda H Crane (Chair), Andrew Calder (Member), Barry Burgan (Member), Catherine McDermott (Member), Christopher Andrews (Member), Duane Kelaart (Member), Gary Brady (Member), Keitha Dunstan (Member), Kenneth Richardson (Member), Michelle Markham (Member), Tanya Forbes (Member), Donna F. Henson (Member), Ray N Moynihan (Member)

1 Oct 2016 → 31 Mar 2019

Activity: Membership › Internal memberships, committees, boards and panelists