Catherine McDermott

Dr

  • Bond University, Faculty of Health Sciences and Medicine

    4229 Gold Coast

    Australia

  • 2534 Citations
  • 12 h-Index
20072018
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Personal profile

Research interests

I completed my Bachelor of Science (Physiology) and PhD at University College in Cork, Ireland, before moving to Australia in 2008.

I have conducted extensive research, with a particular focus on sub-chronic toxicity of organic solvent mixtures in vitro, and also the effects of chemotherapeutic agents on normal bladder function.

As a university lecturer/researcher, I combine a clear understanding of the teaching and learning process with in-depth subject knowledge informed by my own studies and research.

Many bladder cancer patients experience local side-effects following chemotherapy which greatly affect patient quality of life and ability to tolerate treatment. One of my main research interests is to try to understand why these side-effects occur by investigating the effects of chemotherapeutic drugs on normal bladder function. To do this we use in vitro models of the human urothelium. Through these studies we also aim to assess the ability of the urothelium to recover following treatment and determine if there are other drugs that could be used to treat bladder cancer that would be more effective and more tolerable.

Statement for HDR students

These are some of the current HDR projects and students I supervise:

  • Cytotoxic drugs and their effects on bladder function - PhD student - Stanley Kang
  • Cyclophosphamide and Ifosfamide: Mechanisms of urotoxicity and consequences for normal bladder function - PhD student - Kylie Mills
  • Quinazoline based alpha 1-adrenoceptor antagonists and prostate cancer - PhD student - Amanda Forbes
  • Interactions between urothelial mediators regulating release from cultured urothelial cells and porcine urothelial tissue - PhD student - Katrina Smith

 

Education/Academic qualification

PhD

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Research Output 2007 2018

Interstitial Cystitis
Toll-Like Receptor 4
Urinary Bladder
Pain
Anxiety
Urothelium
Streptozocin
Urinary Bladder
Adenosine Triphosphate
Compliance
1 Citations

Differences in statin associated neuroprotection corresponds with either decreased production of IL-1β or TNF-α in an in vitro model of neuroinflammation-induced neurodegeneration

McFarland, A. J., Davey, A. K., McDermott, C. M., Grant, G. D., Lewohl, J. & Anoopkumar-Dukie, S. 1 Apr 2018 In : Toxicology and Applied Pharmacology. 344, p. 56-73 18 p.

Research output: Contribution to journalArticle

Hydroxymethylglutaryl-CoA Reductase Inhibitors
Tumor Necrosis Factor-alpha
Pravastatin
Neurology
Lipopolysaccharides
Ibuprofen
Mitomycin
Urinary Bladder
Caspase 3
Inbred C57BL Mouse
1 Citations

Prazosin but Not Tamsulosin Sensitises PC-3 and LNCaP Prostate Cancer Cells to Docetaxel

Spencer, B. H., McDermott, C. M., Chess-Williams, R., Christie, D. & Anoopkumar-Dukie, S. 17 Apr 2018 In : Pharmacology. 102, 1-2, p. 10-18 9 p.

Research output: Contribution to journalArticle

tamsulosin
docetaxel
Prazosin
Prostatic Neoplasms
Quinazolines

Activities 2016 2016

  • 1 Professional Memberships

Bond University Sage Athena Swan Self-Assessment Team (External organisation)

Crane, L. (Chair), Andrew Calder (Member), Burgan, B. (Member), McDermott, C. (Member), Christopher Andrews (Member), Duane Kelaart (Member), Gary Brady (Member), Dunstan, K. (Member), Kenneth Richardson (Member), Markham, M. (Member), Tanya Forbes (Member), Henson, D. (Member), Moynihan, R. (Member)
1 Oct 201631 Mar 2019

Activity: Professional Memberships

Thesis

Cyclophosphamide and ifosfamide: mechanisms of cytotoxic action and consequences for normal bladder function

Author: Mills, K., 10 Oct 2015

Supervisor: Chess-Williams, R. (Supervisor) & McDermott, C. (Supervisor)

Student thesis: Doctoral Thesis

File

Cytotoxic Drugs and their Effects on Bladder Function

Author: Kang, S. H., 10 Oct 2015

Supervisor: McDermott, C. (Supervisor) & Chess-Williams, R. (Supervisor)

Student thesis: Doctoral Thesis

File

Intravesical gemcitabine treatment: repercussions on normal bladder function.

Author: Farr, S., 2015

Supervisor: McDermott, C. (Supervisor) & Chess-Williams, R. (Supervisor)

Student thesis: Doctoral Thesis

File

Quinazoline-based Alpha1-Adrenoceptor Antagonists and Prostate Cancer

Author: Forbes, A., 8 Oct 2016

Supervisor: McDermott, C. (Supervisor), Chess-Williams, R. (Supervisor) & Anoopkumar-Dukie, S. (Supervisor)

Student thesis: Doctoral Thesis