Research Output per year
Personal profile
Research interests
I completed my Bachelor of Science (Physiology) and PhD at University College in Cork, Ireland, before moving to Australia in 2008.
I have conducted extensive research, with a particular focus on sub-chronic toxicity of organic solvent mixtures in vitro, and also the effects of chemotherapeutic agents on normal bladder function.
As a university lecturer/researcher, I combine a clear understanding of the teaching and learning process with in-depth subject knowledge informed by my own studies and research.
Many bladder cancer patients experience local side-effects following chemotherapy which greatly affect patient quality of life and ability to tolerate treatment. One of my main research interests is to try to understand why these side-effects occur by investigating the effects of chemotherapeutic drugs on normal bladder function. To do this we use in vitro models of the human urothelium. Through these studies we also aim to assess the ability of the urothelium to recover following treatment and determine if there are other drugs that could be used to treat bladder cancer that would be more effective and more tolerable.
Statement for HDR students
These are some of the current HDR projects and students I supervise:
- Cytotoxic drugs and their effects on bladder function - PhD student - Stanley Kang
- Cyclophosphamide and Ifosfamide: Mechanisms of urotoxicity and consequences for normal bladder function - PhD student - Kylie Mills
- Quinazoline based alpha 1-adrenoceptor antagonists and prostate cancer - PhD student - Amanda Forbes
- Interactions between urothelial mediators regulating release from cultured urothelial cells and porcine urothelial tissue - PhD student - Katrina Smith
Education/Academic qualification
PhD
Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.
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Urothelium
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docetaxel
Medicine & Life Sciences
gemcitabine
Medicine & Life Sciences
Mitomycin
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Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Research Output 2007 2018
A central role for toll-like 4 (TLR4) receptors in interstitial cystitis?
Sellers, D. J., McDermott, C. & Chess-Williams, R. 27 Jun 2018 In : American Journal of Physiology - Renal Physiology.Research output: Contribution to journal › Article
Interstitial Cystitis
Toll-Like Receptor 4
Urinary Bladder
Pain
Anxiety
Diabetes-induced alterations in urothelium function: Enhanced ATP release and nerve-evoked contractions in the streptozotocin rat bladder
Lee, S., Rose'meyer, R., McDermott, C., Chess-Williams, R. & Sellers, D. J. 23 Jun 2018 In : Clinical and Experimental Pharmacology and Physiology.Research output: Contribution to journal › Article
Urothelium
Streptozocin
Urinary Bladder
Adenosine Triphosphate
Compliance
Differences in statin associated neuroprotection corresponds with either decreased production of IL-1β or TNF-α in an in vitro model of neuroinflammation-induced neurodegeneration
McFarland, A. J., Davey, A. K., McDermott, C. M., Grant, G. D., Lewohl, J. & Anoopkumar-Dukie, S. 1 Apr 2018 In : Toxicology and Applied Pharmacology. 344, p. 56-73 18 p.Research output: Contribution to journal › Article
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Tumor Necrosis Factor-alpha
Pravastatin
Neurology
Lipopolysaccharides
Ibuprofen decreases spontaneous activity and enhances nerve-evoked contractions to minimize mitomycin c-induced bladder dysfunction
West, E. G., Lang, R., Sellers, D., Chess-Williams, R. & McDermott, C. 1 Aug 2018 In : Journal of Pharmacology and Experimental Therapeutics. 366, 2, p. 282-290 9 p.Research output: Contribution to journal › Article
Ibuprofen
Mitomycin
Urinary Bladder
Caspase 3
Inbred C57BL Mouse
Prazosin but Not Tamsulosin Sensitises PC-3 and LNCaP Prostate Cancer Cells to Docetaxel
Spencer, B. H., McDermott, C. M., Chess-Williams, R., Christie, D. & Anoopkumar-Dukie, S. 17 Apr 2018 In : Pharmacology. 102, 1-2, p. 10-18 9 p.Research output: Contribution to journal › Article
tamsulosin
docetaxel
Prazosin
Prostatic Neoplasms
Quinazolines
Activities 2016 2016
- 1 Professional Memberships
Bond University Sage Athena Swan Self-Assessment Team (External organisation)
Crane, L. (Chair), Andrew Calder (Member), Burgan, B. (Member), McDermott, C. (Member), Christopher Andrews (Member), Duane Kelaart (Member), Gary Brady (Member), Dunstan, K. (Member), Kenneth Richardson (Member), Markham, M. (Member), Tanya Forbes (Member), Henson, D. (Member), Moynihan, R. (Member)1 Oct 2016 → 31 Mar 2019
Activity: Professional Memberships
Thesis
Cyclophosphamide and ifosfamide: mechanisms of cytotoxic action and consequences for normal bladder function
Author: Mills, K., 10 Oct 2015Supervisor: Chess-Williams, R. (Supervisor) & McDermott, C. (Supervisor)
Student thesis: Doctoral Thesis
File
Cytotoxic Drugs and their Effects on Bladder Function
Author: Kang, S. H., 10 Oct 2015Supervisor: McDermott, C. (Supervisor) & Chess-Williams, R. (Supervisor)
Student thesis: Doctoral Thesis
File
Intravesical gemcitabine treatment: repercussions on normal bladder function.
Author: Farr, S., 2015Supervisor: McDermott, C. (Supervisor) & Chess-Williams, R. (Supervisor)
Student thesis: Doctoral Thesis
File
Quinazoline-based Alpha1-Adrenoceptor Antagonists and Prostate Cancer
Author: Forbes, A., 8 Oct 2016Supervisor: McDermott, C. (Supervisor), Chess-Williams, R. (Supervisor) & Anoopkumar-Dukie, S. (Supervisor)
Student thesis: Doctoral Thesis