Organization profile

Profile Information

The Centre supports studies in stem cell biology and regenerative medicine with an emphasis on translational research for therapeutic benefit. Current research is supported by expertise in stem cell differentiation, tissue organogenesis and regeneration, biomaterials and tissue engineering, and surgery for transplantation, involving several interrelated projects.

Vision: The Centre has a major focus on retinal degenerative diseases and was originally established to develop stem cell therapy for Age-related Macular Degeneration (AMD). The goal has been to prepare a cell-on-membrane construct for implantation of retinal cells into the eye to replace cells damaged by AMD. The Centre currently holds patents on the preparation of ultrathin membranes. Procedures for production of clinical grade retinal cells from stem cells are under patent application. 

Blood cells:  Hematopoietic stem cells (HSC) remain the only US Food and Drug Administration (FDA) approved stem cell therapy. Many questions abound about the best source of HSC for transplantation. The Centre is investigating HSC heterogeneity and the changes they adopt following stress, infection and ageing.

Organogenesis: Only a few adult tissues including liver and spleen have capacity to regenerate. An important breakthrough in the Centre has been the identification of a ‘stromal organiser cell’ which regenerates spleen, supporting development of a sinusoidal network which underlies tissue compartments supporting hematopoiesis and immunity.

Fingerprint Dive into the research topics where Clem Jones Centre for Regenerative Medicine is active. These topic labels come from the works of this organisation's members. Together they form a unique fingerprint.

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    Profiles

    Photo of Jason Limnios

    Jason Limnios

    Person: Doctor of Philosophy, Research Only

    20092019
    Photo of Helen O'Neill

    Helen O'Neill

    Person: Research Only

    19762019

    Research Output

    Advancing a stem cell therapy for age-related macular degeneration

    O'Neill, H. C., Limnios, I. J. & Barnett, N. L., 17 Dec 2019, In : Current stem cell research & therapy.

    Research output: Contribution to journalArticleResearchpeer-review

  • A novel myeloid cell in murine spleen defined through gene profiling

    Hey, Y. Y., O'Neill, T. & O'Neill, H. C., 1 Aug 2019, In : Journal of Cellular and Molecular Medicine. 23, 8, p. 5128-5143 16 p., 14382.

    Research output: Contribution to journalArticleResearchpeer-review

    Open Access
    File
  • 104 Downloads (Pure)

    A rapid technique to quantify retinal oxidative stress and the protection provided by novel nitroxide-based antioxidant / anti-inflammatory compounds

    Barnett, N. L., Bottle, S. E., Tong, J., Thomas, K. & Rayner, C. L., Jul 2019, In : Investigative Ophthalmology and Visual Science. 60, 9, 2 p.

    Research output: Contribution to journalMeeting AbstractResearchpeer-review

    Open Access

    Activities

    • 3 Professional Memberships
    • 2 Talk or Presentation Outside of an Organised Event
    • 1 Editorial Board Member
    • 1 Oral presentation

    Australasian Society for Stem Cell Research (External organisation)

    Don Lim (Member)
    2018 → …

    Activity: MembershipProfessional Memberships

    International Society for Stem Cell Research (External organisation)

    Don Lim (Member)
    2018

    Activity: MembershipProfessional Memberships

    International Society for Experimental Hematology (External organisation)

    Don Lim (Member)
    2018

    Activity: MembershipProfessional Memberships

    Press / Media

    Bond receives multi-million dollar private donation to fund stem cell research

    Helen C O'Neill & Timothy J. Brailsford

    24/11/1729/11/17

    4 items of Media coverage

    Press/Media: Expert Comment

    Bond adds new chair in biology

    Helen Christine O'Neill

    21/07/15

    1 item of Media coverage

    Press/Media: Expert Comment