Organization profile

Profile Information

The Centre supports studies in stem cell biology and regenerative medicine with an emphasis on translational research for therapeutic benefit. Current research is supported by expertise in stem cell differentiation, tissue organogenesis and regeneration, biomaterials and tissue engineering, and surgery for transplantation, involving several interrelated projects.

Vision: The Centre has a major focus on retinal degenerative diseases and was originally established to develop stem cell therapy for Age-related Macular Degeneration (AMD). The goal has been to prepare a cell-on-membrane construct for implantation of retinal cells into the eye to replace cells damaged by AMD. The Centre currently holds patents on the preparation of ultrathin membranes. Procedures for production of clinical grade retinal cells from stem cells are under patent application. 

Blood cells:  Hematopoietic stem cells (HSC) remain the only US Food and Drug Administration (FDA) approved stem cell therapy. Many questions abound about the best source of HSC for transplantation. The Centre is investigating HSC heterogeneity and the changes they adopt following stress, infection and ageing.

Organogenesis: Only a few adult tissues including liver and spleen have capacity to regenerate. An important breakthrough in the Centre has been the identification of a ‘stromal organiser cell’ which regenerates spleen, supporting development of a sinusoidal network which underlies tissue compartments supporting hematopoiesis and immunity.

Fingerprint The fingerprint is based on mining the text of the scientific documents related to the associated persons. Based on that an index of weighted terms is created, which defines the key subjects of research unit

Spleen Medicine & Life Sciences
Dendritic Cells Medicine & Life Sciences
Hematopoiesis Medicine & Life Sciences
Stromal Cells Medicine & Life Sciences
Myeloid Cells Medicine & Life Sciences
Hematopoietic Stem Cells Medicine & Life Sciences
Bruch Membrane Medicine & Life Sciences
Regeneration Medicine & Life Sciences

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Research Output 2011 2019

Identification of stromal cells in spleen which support myelopoiesis

Lim, H. & O'Neill, H. C., 8 Jan 2019, (Accepted/In press) In : Frontiers in Cell and Developmental Biology. 7, 1, 425328.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Myelopoiesis
Stromal Cells
Spleen
Hematopoiesis
Cell Fractionation

Platypus Induced Pluripotent Stem Cells: the Unique Pluripotency Signature of a Monotreme

Whitworth, D. J., Limnios, J. I., Gauthier, M-E., Weeratunga, P., Ovchinnikov, D. A., Baillie, G., Grimmond, S. M., Graves, J. A. M. & Wolvetang, E. J., 1 Feb 2019, In : Stem Cells and Development. 28, 3, p. 151-164 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Platypus
monotreme
Induced Pluripotent Stem Cells
Pluripotent Stem Cells
X-Linked Genes

Ultrasound-Responsive Nanobubbles for Enhanced Intravitreal Drug Migration: An Ex Vivo Evaluation

Thakur, S. S., Chen, Y-S., Houston, Z. H., Fletcher, N., Barnett, N. L., Thurecht, K. J., Rupenthal, I. D. & Parekh, H. S., 1 Mar 2019, In : European Journal of Pharmaceutics and Biopharmaceutics. 136, 136, p. 102-107 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Pharmaceutical Preparations
Swine
Vitreous Body
Rhodamines
Temazepam

Datasets

Macular regeneration

Liu, Q. (Creator), Bond University, 2013

Dataset

Activities 2015 2019

Bond University Research Integrity Advisor

Nigel L Barnett (Supervisor)
20192021

Activity: Other

International Society for Experimental Hematology (External organisation)

Don Lim (Member)
2018

Activity: MembershipProfessional Memberships

Australasian Society for Stem Cell Research (External organisation)

Don Lim (Member)
2018 → …

Activity: MembershipProfessional Memberships

Press / Media

Bond receives multi-million dollar private donation to fund stem cell research

Helen O'Neill

24/11/1729/11/17

4 items of media coverage

Press/Media: Expert Comment

Bond adds new chair in biology

Helen O'Neill

21/07/15

1 item of media coverage

Press/Media: Expert Comment