MD Supervision - Lauren Canning

Activity: Professional Development, Mentorship, Supervision and Other ActivitiesNon-HDR Student Supervision


Assessing the role of Matrix metalloproteinase 14 in prostate cancer progression – a systematic review (MD project)

The aim of this project is to assess the role of MMP14 in prostate cancer progression by exploring the current literature to

-uncover links between MMP14 and prostate cancer,
-understand the mechanisms through which MMP14 can promote prostate cancer progression, and
-assess the clinical significance of MMP14 in prostate cancer.

Additional information

Prostate cancer is the second most common cancer diagnosed in men in Australia and the third most common cause of cancer death. Due to advancement in treatments for localised prostate cancer, where prognosis is generally good, patient mortality is increasingly linked to metastatic disease status.

Matrix metalloproteinases (MMPs) are a group of enzymes responsible for the turnover of extracellular matrix and other biologically active proteins. MMPs are therefore essential to many physiological processes such as embryonic development and wound healing. However, MMPs have also been implicated with pathological processes including cancer.

Considered the ‘master’ MMP, Matrix metalloproteinase 14 (MMP14) is normally expressed in many different cell types but its expression has been reported to be up regulated for some types of cancer with its expression correlating with poor prognosis. However, the role of MMP14 in promoting prostate cancer progression and metastasis is not fully understood.
PeriodJul 2022Oct 2023